Organisation profile
Organisation profile
ITM's Experimental Immunology Unit (Simões Lab) was established in May 2023 and is the only laboratory in Belgium focusing on the innate immunity of malaria vectors, for the discovery of novel mosquito-based malaria control genetic technologies. Our research focuses on understanding how biotic and abiotic factors, such as pathogen infections and environmental variables, contribute to shaping the innate immunity responses of the Anopheles vector (the malaria mosquito) at the genetic, molecular, and mechanistic levels, with consequences for Plasmodium (the malaria parasite) infection and malaria transmission.
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Profiles
Projects
- 1 Active
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CLIMMAT: Impact of environmental change on mosquito immunity: implications for malaria transmission control
Simoes, M. L. (PI) & Simoes, M. L. (Promotor)
Flemish Government - Department of Work, Economy, Science, Innovation
1/01/25 → 31/12/28
Project: Research Project
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Beyond the static lab: environmental variability in genetically modified mosquito target gene identification for malaria control
Dael, L. & Simoes, M. L., Jun-2026, In: Current Opinion in Insect Science. 75, 7 p., 101489.Research output: Contribution to journal › Review › peer-review
Open Access -
Fluctuating warm and humid conditions differentially impact immunity and development in the malaria vector Anopheles stephensi
Lemos-Silva, T., De Neef, E., Valgaerts, Y. & Simões, M. L., 2025, In: Global Change Biology. 31, 8, 12 p., e70382.Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review
Open Access -
Targeting the mosquito prefoldin-chaperonin complex blocks Plasmodium transmission
Dong, Y., Kang, S., Sandiford, S., Pike, A., Simoes, M., Ubalee, R., Kobylinski, K. & Dimopoulos, G., Apr-2025, In: Nature Microbiology. 10, 4, p. 841-854 28 p.Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review