Projects per year
Organization profile
Organisation profile
Introduction
The Unit of Malariology, led by Prof Rosanas-Urgell, aims to contribute to the development of tools and strategies for better malaria control and elimination. Most of our studies are solidly grounded in field-research and epidemiological studies aiming to provide a bridge between in vitro and in vivo research. We combine state-of-the-art molecular, ‘omic and cell technologies with field-research to study how Plasmodium parasites adapt to a changing environment. In this endeavor we count on a strong network of collaborations in Europe, Africa, South America, South-East Asia and Oceania.
Main activities
Lines of research in the unit are:
. We investigate mechanisms and regulation of P. vivax key biological processes such as development of drug resistance and red blood cell invasion, using ex vivo invasion assays, CRISPR-Cas9 technology, P. knowlesi model and single-cell-sequencing.
. We work to develop molecular tools with next generation sequencing (NGS) approaches to support surveillance, monitoring, evaluation and improvement of current malaria control and elimination strategies. We support the transfer of technology, training and supervision to laboratories in malaria endemic areas (https://mesamalaria.org/mesa-track/development-tools-and-strategies-malaria-molecular-surveillance-countries-included-peru).
. By using molecular epidemiology studies and fundamental research we investigate how host and environmental factors (host genetics, treatment, immunity and seasonality) impact Plasmodium transmission.
Besides research, we provide ISO15189 accredited molecular diagnostic services for Plasmodium in the context of clinical trials, NGO projects and quality control.
We are strongly committed to knowledge dissemination with the training of a future generation of excellent scientist at different levels (bachelor, master and PhD) and from diverse backgrounds. We co-organize the Master of Science in Tropical Medicine and the annual course on Molecular Data for Infectious Diseases (https://edu.itg.be/course/component/69) while we contribute to formal teaching activities nationally and internationally.
Contact
Please do not hesitate to email us for more information.
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Network
Profiles
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Genetic Structure of Malaria Parasites Obtained Over a Ten Year Period from Patients Residing in the Diverse Ecosystem of Kenya
Nyataya, J. N., Rosanas-Urgell, A., Kattenberg, J. H., Waitumbi, J. & Dujardin, J.
1/01/23 → …
Project: PhD-project
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The development of chloroquine resistance in Plasmodium vivax parasites
Sauve, E., Rosanas-Urgell, A., Dujardin, J., Kattenberg, J. H. & Dujardin, J.
27/04/21 → …
Project: PhD-project
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VIVAX RES: Mechanisms of P. vivax chloroquine resistance: a transcriptomic/transgenic approach
Rosanas-Urgell, A., Kattenberg, J. H., Domagalska, M., Monsieurs, P. & Stas, M.
1/01/21 → 31/12/24
Project: Research Project
Research output
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Band 3-mediated Plasmodium vivax invasion is associated with transcriptional variation in PvTRAg genes
De Meulenaere, K., Prajapati, S. K., Villasis, E., Cuypers, B., Kattenberg, J. H., Kasian, B., Laman, M., Robinson, L. J., Gamboa, D., Laukens, K. & Rosanas-Urgell, A., 2022, In: Frontiers in Cellular and Infection Microbiology. 12, p. 1011692Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Novel highly-multiplexed AmpliSeq targeted assay for Plasmodium vivax genetic surveillance use cases at multiple geographical scales
Kattenberg, J. H., Nguyen, H. V., Nguyen, H. L., Sauve, E., Nguyen, N. T. H., Chopo-Pizarro, A., Trimarsanto, H., Monsieurs, P., Guetens, P., Nguyen, X. X., Van Esbroeck, M., Auburn, S., Nguyen, B. T. H. & Rosanas-Urgell, A., 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 24 p., 953187.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Parvovirus B19-associated transient aplastic crisis following P. falciparum malaria and post-artesunate delayed haemolysis in a returning traveller
Huits, R., Van Ierssel, S., Rosanas-Urgell, A., Van den Bossche, D. & Bottieau, E., 2022, In: Journal of Travel Medicine. 29, 4Research output: Contribution to journal › A1: Web of Science-article › peer-review