Projects per year
Organization profile
Organisation profile
Introduction
In the Unit of Molecular Parasitology, the focus lays on Leishmania, with a particular attention on drug-resistance and associated phenotypes (drug resistant parasites are also more virulent). Genomics and metabolomics are running since 4 years and we now enter the phase of functional testing of the importance of gene dosage in the survival skills of the parasite; integration in a true systems biology approach (through the addition of transcriptomic and proteomic layers) is considered. We also aim to develop methods allowing direct whole genome sequencing in (sub)clinical samples as well as single cell genomics.
Jean-Claude Dujardin is the head of the Unit of Molecular Parasitology since 2002.
Main activities
- Drug resistance in leishmaniasis: mechanisms, link with survival skills, in vitro and in vivo phenotyping, experimental validation, surveillance tools, interacting closely with ‘clinomics’ line; our expertise in drug resistance is also used to support R&D for new antileishmania drugs
- ‘Clinomic’ diversity in leishmania: genomic, transcriptomic, metabolomic exploitation of parasite collections linked to well-documented cohorts of patients (understanding of clinical and in vitro/vivo phenotypic diversity, parasite evolution)
- Molecular epidemiology of leishmaniasis: (i) further dissemination of standardized and QA-typing tests and (ii) application of molecular tools for characterization of transmission patterns (with a special interest for asymptomatic infections)
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Profiles
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Viral evolutionary analyses as magnifying glass on parasite population dynamics
Heeren, S., Dujardin, J., Dujardin, J., Van den Broeck, F., Lemey, P. & Van den Broeck, F.
30/06/21 → …
Project: PhD-project
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The development of chloroquine resistance in Plasmodium vivax parasites
Sauve, E., Rosanas-Urgell, A., Dujardin, J., Kattenberg, J. H. & Dujardin, J.
27/04/21 → …
Project: PhD-project
Research output
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Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1-like protein in the mechanism of resistance to a novel antileishmanial compound
Hefnawy, A., Negreira, G., Jara, M., Cotton, J. A., Maes, I., D'Haenens, E., Imamura, H., Cuypers, B., Monsieurs, P., Mouchtoglou, C., De Winter, H., Pintelon, I., Timmermans, J-P., Berriman, M., Sanders, M., Martin, J., de Muylder, G., Dujardin, J-C., Sterckx, Y. G-J. & Domagalska, M. A., 2022, In : MBio. p. e0326421Research output: Contribution to journal › A1: Web of Science-article
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A community resource for paired genomic and metabolomic data mining
Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., Brejnrod, A. & 90 others, , 2021, In : Nature Chemical Biology. 17, 4, p. 363-368 6 p.Research output: Contribution to journal › Comment/debate
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Amino-substituted 3-aryl- and 3-heteroarylquinolines as potential antileishmanial agents
Hammill, J. T., Sviripa, V. M., Kril, L. M., Ortiz, D., Fargo, C. M., Kim, H. S., Chen, Y., Rector, J., Rice, A. L., Domagalska, M. A., Begley, K. L., Liu, C., Rangnekar, V. M., Dujardin, J-C., Watt, D. S., Landfear, S. M. & Guy, R. K., 2021, In : Journal of Medicinal Chemistry. 64, 16, p. 12152-12162 11 p.Research output: Contribution to journal › A1: Web of Science-article