Projects per year
In the Unit of Molecular Parasitology, the focus lays on Leishmania, with a particular attention on drug-resistance and associated phenotypes (drug resistant parasites are also more virulent). Genomics and metabolomics are running since 4 years and we now enter the phase of functional testing of the importance of gene dosage in the survival skills of the parasite; integration in a true systems biology approach (through the addition of transcriptomic and proteomic layers) is considered. We also aim to develop methods allowing direct whole genome sequencing in (sub)clinical samples as well as single cell genomics.
Jean-Claude Dujardin is the head of the Unit of Molecular Parasitology since 2002.
- Drug resistance in leishmaniasis: mechanisms, link with survival skills, in vitro and in vivo phenotyping, experimental validation, surveillance tools, interacting closely with ‘clinomics’ line; our expertise in drug resistance is also used to support R&D for new antileishmania drugs
- ‘Clinomic’ diversity in leishmania: genomic, transcriptomic, metabolomic exploitation of parasite collections linked to well-documented cohorts of patients (understanding of clinical and in vitro/vivo phenotypic diversity, parasite evolution)
- Molecular epidemiology of leishmaniasis: (i) further dissemination of standardized and QA-typing tests and (ii) application of molecular tools for characterization of transmission patterns (with a special interest for asymptomatic infections)
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30/06/21 → …
27/04/21 → …
A framework to deduce the convoluted repertoire and epitope hierarchy of human T cell responses in visceral leishmaniasis: patient meets in silico
3/11/20 → …
& 90 others, , 2021, In : Nature Chemical Biology. 17, 4, p. 363-368 6 p.
Research output: Contribution to journal › Comment/debate
Assessing L. donovani skin parasite load: a proof of concept study of a microbiopsy device in an Indian settingCloots, K., Singh, O. P., Singh, A. K., Van der Auwera, G., Kumar, P., Gedda, M. R., Rai, T. K., Hasker, E., Sundar, S. & Boelaert, M., 2021, In : Frontiers in Cellular and Infection Microbiology. 11, 9 p., 645121.
Research output: Contribution to journal › A1: Web of Science-articleOpen AccessFile1 Downloads (Pure)
Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancerBoullosa, L. F., Van Loenhout, J., Flieswasser, T., De Waele, J., Hermans, C., Lambrechts, H., Cuypers, B., Laukens, K., Bartholomeus, E., Siozopoulou, V., De Vos, W. H., Peeters, M., Smits, E. L. J. & Deben, C., 2021, In : Redox Biology. 42, 17 p., 101949.
Research output: Contribution to journal › A1: Web of Science-article