Projects per year
Organization profile
Organisation profile
The Protozoology Research Group is comprised of three research units (Molecular Parasitology, Trypanosoma, and Malariology) performing basic and translational research on three major vector-borne protozoan parasites responsible for devastating diseases in humans and animals across the developing world: Leishmania (human leishmaniasis), Plasmodium (human malaria), Trypanosoma (human and animal African trypanosomiasis). Intensive control and elimination efforts are currently ongoing to eliminate visceral leishmaniasis in the Indian subcontinent, malaria in the three continents and HAT in Africa. Our research is closely connected to this as the acquired new knowledge and its translation into innovative tools for diagnosis and surveillance will enhance the ongoing disease-control/elimination programmes and their follow-up.
The main common goal that drives the basic research within the group is, by using state-of-the-art molecular, cell biology, and computational technologies, to improve our understanding of the parasite biology and adaptation mechanisms to different micro-environments in its hosts (including anti-parasite drug pressure) and the parasite-host molecular interplay that drives these mechanisms. Moreover, we study the impact of the adaptation on the parasite genetic and phenotypic heterogeneity within the host, both at individual and population level and on the parasite transmission.
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Profiles
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Genetic Structure of Malaria Parasites Obtained Over a Ten Year Period from Patients Residing in the Diverse Ecosystem of Kenya
Nyataya, J. N., Rosanas-Urgell, A., Kattenberg, J. H., Waitumbi, J. & Dujardin, J.
1/01/23 → …
Project: PhD-project
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IMMETASEX: Host immune and metabolic determinants of sexual conversion in Plasmodium parasites
Rosanas-Urgell, A., Cortés, A., Janse, C., Franke-Fayard, B. & Stas, M.
Fonds voor Wetenschappelijk Onderzoek
1/01/23 → 31/12/26
Project: Research Project
Research output
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Malaria molecular surveillance in the Peruvian Amazon with a novel highly multiplexed Plasmodium falciparum AmpliSeq assay
Kattenberg, J. H., Fernandez-Miñope, C., van Dijk, N. J., Llacsahuanga Allcca, L., Guetens, P., Valdivia, H. O., Van Geertruyden, J-P., Rovira-Vallbona, E., Monsieurs, P., Delgado-Ratto, C., Gamboa, D. & Rosanas-Urgell, A., 2023, (E-pub ahead of print) In: Microbiology Spectrum. 21 p., e0096022.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Molecular surveillance of malaria using the PF AmpliSeq custom assay for Plasmodium falciparum parasites from dried blood spot DNA isolates from Peru
Kattenberg, J. H., Van Dijk, N. J., Fernández-Miñope, C. A., Guetens, P., Mutsaers, M., Gamboa, D. & Rosanas-Urgell, A., 2023, In: Bio-Protocol. 13, 5, p. e4621 23 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples
MalariaGEN, 2023, In: Wellcome Open Research. 8, p. 22Research output: Contribution to journal › A1: Web of Science-article › peer-review