Projects per year
The Protozoology Research Group is comprised of three research units (Molecular Parasitology, Trypanosoma, and Malariology) performing basic and translational research on three major vector-borne protozoan parasites responsible for devastating diseases in humans and animals across the developing world: Leishmania (human leishmaniasis), Plasmodium (human malaria), Trypanosoma (human and animal African trypanosomiasis). Intensive control and elimination efforts are currently ongoing to eliminate visceral leishmaniasis in the Indian subcontinent, malaria in the three continents and HAT in Africa. Our research is closely connected to this as the acquired new knowledge and its translation into innovative tools for diagnosis and surveillance will enhance the ongoing disease-control/elimination programmes and their follow-up.
The main common goal that drives the basic research within the group is, by using state-of-the-art molecular, cell biology, and computational technologies, to improve our understanding of the parasite biology and adaptation mechanisms to different micro-environments in its hosts (including anti-parasite drug pressure) and the parasite-host molecular interplay that drives these mechanisms. Moreover, we study the impact of the adaptation on the parasite genetic and phenotypic heterogeneity within the host, both at individual and population level and on the parasite transmission.
Dive into details
Select a country/territory to view shared publications and projects
Molecular basis for the potency and selectivity of DNDI-6690, a promising lead for the development of novel anti-leishmanial drugs
Wuyts, E., Dujardin, J., Sterckx, Y. G. & Caljon, G.
27/04/22 → …
Cellular, molecular and functional characterization of quiescence in Leishmania donovani, the etiological agent of visceral leishmaniasis
27/04/22 → …
INNATEBITE: Innate immune response in the mammalian host skin after the bite of a trypanosome-infected tsetse fly
1/01/22 → 31/12/25
Project: Research Project
Diagnostic performance of three rK39 rapid diagnostic tests and two direct agglutination tests for the diagnosis of visceral leishmaniasis in Southern IranRezaei, Z., Pourabbas, B., Kühne, V., Pourabbas, P. & Büscher, P., 2022, In: Journal of Tropical Medicine. 2022, p. 3569704
Research output: Contribution to journal › A1: Web of Science-article › peer-reviewOpen AccessFile7 Downloads (Pure)
Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1-like protein in the mechanism of resistance to a novel antileishmanial compoundHefnawy, A., Negreira, G., Jara, M., Cotton, J. A., Maes, I., D'Haenens, E., Imamura, H., Cuypers, B., Monsieurs, P., Mouchtoglou, C., De Winter, H., Pintelon, I., Timmermans, J-P., Berriman, M., Sanders, M., Martin, J., de Muylder, G., Dujardin, J-C., Sterckx, Y. G-J. & Domagalska, M. A., 2022, In: MBio. 13, 1, 15 p., e0326421.
Research output: Contribution to journal › A1: Web of Science-article › peer-reviewOpen AccessFile55 Downloads (Pure)
High throughput single-cell genome sequencing gives insights into the generation and evolution of mosaic aneuploidy in Leishmania donovaniNegreira, G. H., Monsieurs, P., Imamura, H., Maes, I., Kuk, N., Yagoubat, A., Van den Broeck, F., Sterkers, Y., Dujardin, J-C. & Domagalska, M. A., 2022, In: Nucleic Acids Research. 50, 1, p. 293-305 13 p.
Research output: Contribution to journal › A1: Web of Science-article › peer-reviewOpen AccessFile9 Downloads (Pure)