Projects per year
Organisation profile
Organisation profile
Introduction
The Trypanosoma Unit, led by Prof Jan Van Den Abbeele, focuses its activities on African trypanosomes, protozoan parasites that causes devastating diseases in humans (Human African trypanosomiasis or sleeping sickness) and livestock (Animal trypanosomiasis). Activities reach from basic research to translational, field-oriented work. The major aims of our work are to extend our understanding of i) the parasite adaptive changes during key life cycle stages and its interplay with the host micro-environments and ii) the mechanisms of parasite drug resistance acquisition. Besides, we develop and/or optimize methods for improved parasite diagnosis and molecular surveillance. The outcome of our activities will lead to the development of novel approaches contributing to an improved control of the diseases in humans and/or livestock and its surveillance in the field.
Main activities
Our major research lines include fundamental biology of the trypanosome parasite (Trypanosoma brucei sp. and T. congolense) with focus on key stages in the parasite life cycle such as the final metacyclic stage in the tsetse fly salivary glands or mouthparts, and the early development in the host skin, after transmission through tsetse bite. Here, we study the host innate immune response and the role of parasite and tsetse saliva components in modulating this skin immune environment. In addition, the role of specific parasite surface proteins at this developmental stage are being studied including their potential to be targeted by vaccination to hamper the infection at this early stage in the mammalian host. Other basic research of our unit focuses on the mechanism of drug transport and the acquisition of drug resistance in the livestock trypanosomes.
Our major translational research line focuses on the refinement and validation of (q)PCR-based tools to identify the human T. brucei gambiense parasite in various host tissue samples (of humans as well as animals) and to be used as a sensitive and specific diagnostic instrument. This activity is closely linked with the various sleeping sickness elimination programs that are coordinated by ITM (Dept. Public health).
As WHO Collaborating Centre for Research and Training on Human African Trypanosomiasis, we perform reference testing and external quality control for gambiense-HAT diagnosis and provide training and support to national HAT-reference labs in endemic countries.
The Unit has one of the largest and most diverse collections of well documented T. brucei gambiense and T. congolense field-isolated strains worldwide.
Besides supervising students at various levels (bachelor, master, and PhD), we lecture on vector-borne diseases including sleeping sickness, on laboratory diagnostics and on basic molecular biology at ITM.
Contact
Please do not hesitate to email us for more information.
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Collaborations and top research areas from the last five years
Profiles
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Exploring the non-coding RNA in tsetse fly saliva and its effect on the host innate immune response and trypanosome development at the host skin bite site.
Odhiambo, P. O., Van Den Abbeele, J., Monsieurs, P., Dujardin, J. & Masiga, D.
1/01/24 → …
Project: PhD-project
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Development and validation of next-generation serodiagnostics for the elimination of Trypanosoma brucei gambiense human African trypanosomiasis.
Tablado Alonso, S., Hasker, E., Rigouts, L., Van Den Abbeele, J. & Mumba-Ngoyi, D.
8/06/23 → …
Project: PhD-project
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TRYPTACKLE: Tackling the livestock parasite Trypanosoma congolense by targeting invariant surface proteins
Van Den Abbeele, J., Sterckx, Y. & Van Den Abbeele, J.
Flemish Government - Department of Work, Economy, Science, Innovation
1/01/23 → 31/12/26
Project: Research Project
Research output
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Can cutaneous leishmaniasis provoke a resurgence of kala-azar in the Indian subcontinent?
Bhattarai, NR., Rai, K., Uranw, S., Khadka, DK., Khanal, B., Dahal, G., Pradhan, S., Dhakal, S., Monsieurs, P., de Gooyer, T., Cloots, K., Hasker, E. & van der Auwera, G., 2025, In: BMC Infectious Diseases. 25, 7 p., 281.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open Access -
Evaluation of two candidate molecules-TCTP and cecropin-on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis
Freitas, FSN., De Vooght, L., Njiokou, F., Van Den Abeele, J., Bossard, G., Tchicaya, B., Corrales, RM., Ravel, S., Geiger, A. & Berthier-Teyssedre, D., 2025, (E-pub ahead of print) In: Insect Science. 14 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open Access -
Evidence for a model of conformational change by the Plasmodium falciparum circumsporozoite protein during sporozoite development in the mosquito host through the use of camelid single-domain antibodies
Geens, R., De Vocht, L., Aguirre-Botero, MC., Vincke, C., Romäo, E., Magez, S., Muyldermans, S., Amino, R. & Sterckx, YGJ., 2025, (E-pub ahead of print) In: Infection and Immunity. 20 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open Access