Projects per year
Personal profile
Research expertise
Leen Rigouts graduated as a Master in Biological Science in 1987, and successfully completed a postgraduate course on Tropical Medicine (ITM) in 1988.
In 1989 she joined the Unit of Mycobacteriology at ITM, and executed various studies on serological diagnosis of tuberculosis (TB), identification of mycobacteria by fatty-acid analyses, and molecular epidemiology of bovine and human TB. The latter was the subject of her PhD thesis defended in 2000.
Since then she supervised and accomplished studies covering various aspects of human and bovine TB:
Molecular epidemiology studies on reinfection versus reactivation, prevalence of multiple M. tuberculosis infections, and transmission rates among MDR and non-MDR TB
Drug-resistance studies on its prevalence and incidence various geographic regions, rapid detection of drug resistance by molecular tools, development of drug-resistance, resistance to second-line drugs, and alternative ways for TB treatment
Studies on the zoonotic aspect of bovine TB
Studies investigating social aspects of TB
These projects were conducted in collaboration with Belgian and international universities and research centers, as well as some non-governmental organizations. Research activities are currently conducted in Bangladesh, Cambodia, Georgia, Ethiopia and Peru, with a strong focus on drug resistance mechanisms.
In 2004, the Unit of Mycobacteriology obtained the ISO15189 accreditation for clinical laboratories and successfully maintained it thereafter under Leen Rigout’s leadership. Leen was actively involved in designing the new L2/L3 facilities for TB, and writing the respective biosafety guidelines. This expertise is now frequently consulted by international collaborating centers. She is member of various scientific expert committees like BELTA-TBnet and the New Diagnostic Working Group of the StopTB Partnership.
In 2011, part of the unit’s research collection became publically available through the ISO9001-certified BCCM/ITM mycobacterial culture collection, managed by Leen Rigouts.
Since 2008 she is professor in tropical infectious diseases at the University of Antwerp (UA), and from the start at ITM she was mentor of many bachelor and master student. Under her promotorship, two students have graduated as PhD, and about 6 are currently being supervised and guided.
Education/Academic qualification
Biological Sciences, PhD, Ghent University
Award Date: 15-Jun-2000
Tropical Medicine, Post-graduate, Institute of Tropical Medicine
Award Date: 25-Mar-1988
Biological Sciences, Master, Ghent University
Award Date: 1-Sep-1987
External positions
University of Antwerp
1-Oct-2008 → …Keywords
- B110-medical-informatics
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Collaborations and top research areas from the last five years
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Culturing from Tongue Swabs
Rigouts, L., de Jong, B., Hassane Harouna, S. & de Jong, B.
Foundation for Innovative New Diagnostics
12/12/22 → 15/12/23
Project: Research Project
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TB/NTM Research Cluster
de Jong, B., Sengstake, S., Rigouts, L., Tzfadia, O., Ardizzoni, E., Lynen, L., Decroo, T., Hasker, E., Van Rie, A., Lynen, L. & Hasker, E.
1/01/22 → 31/12/26
Project: Research Project
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FA5 RWANDA: Make Rwandan institutes leaders in infectious disease prevention, diagnosis and control
Rigouts, L., Rosanas-Urgell, A., Kattenberg, E., de Jong, B., Cuella Martin, I., Mitchell, E., Theunissen, C., Polman, K., Trevisan, C., Ravinetto, R., Roosen, T. & de Jong, B.
Directorate-General for Development Cooperation and Humanitarian Aid
1/01/22 → 31/12/26
Project: Development project
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BCCM: Consolidation and management of the BCCM Consortium as a "Belgian Research Center".
de Jong, B., Rigouts, L., Cogneau, S. & de Jong, B.
1/01/22 → 31/12/24
Project: Research Project
Research output
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Face mask sampling (FMS) for tuberculosis shows lower diagnostic sensitivity than sputum sampling in Guinea
Hassane-Harouna, S., Braet, S. M., Decroo, T., Camara, L. M., Delamou, A., Bock, S. D., Ortuño-Gutiérrez, N., Cherif, G-F., Williams, C. M., Wisniewska, A., Barer, M. R., Rigouts, L. & de Jong, B. C., 2023, In: Annals of Clinical Microbiology and Antimicrobials. 22, 1, 7 p., 81.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile -
GeneXpert MTB/RIF Ultra performance to detect uncommon rpoB mutations in Mycobacterium tuberculosis
Rigouts, L., Keysers, J., Rabab, R., Fissette, K., van Deun, A. & de Jong, B. C., 2023, In: BMC Research Notes. 16, 1, 146.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile14 Downloads (Pure) -
Mycobacterium tuberculosis retains viability in RNAlater buffer but not in GTC-TCEP and DNA/RNA Shield
Krausser, L., Braet, S. M., Benaamar, Z., Van Dyck-Lippens, M., de Jong, B. C. & Rigouts, L., 2023, In: Diagnostic Microbiology and Infectious Disease. 106, 1, p. 115905 3 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile20 Downloads (Pure) -
Prolonged heating should be avoided during the preparation of Delamanid containing Middlebrook 7H11 medium
Rupasinghe, R. A. P., Reenaers, R., Vereecken, J., Sengstake, S., Rigouts, L. & de Jong, B., 25-Jun-2023.Research output: Contribution to conference › Poster › peer-review
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Re-evaluation of Critical Concentrations of Antituberculosis Fluoroquinolones in the Mycobacteria Growth Indicator Tube 960 System
Rupasinghe, R. A. P., Vereecken, J., de Jong, B., Rigouts, L. & Driesen, M., 15-Sep-2023, In: International Journal of Mycobacteriology. p. 316-323 7 p., 144_23.Research output: Contribution to journal › A2: International peer reviewed article (not A1-type) › peer-review