Projects per year
Personal profile
Research expertise
Leen Rigouts graduated as a Master in Biological Science in 1987, and successfully completed a postgraduate course on Tropical Medicine (ITM) in 1988.
In 1989 she joined the Unit of Mycobacteriology at ITM, and executed various studies on serological diagnosis of tuberculosis (TB), identification of mycobacteria by fatty-acid analyses, and molecular epidemiology of bovine and human TB. The latter was the subject of her PhD thesis defended in 2000.
Since then she supervised and accomplished studies covering various aspects of human and bovine TB:
Molecular epidemiology studies on reinfection versus reactivation, prevalence of multiple M. tuberculosis infections, and transmission rates among MDR and non-MDR TB
Drug-resistance studies on its prevalence and incidence various geographic regions, rapid detection of drug resistance by molecular tools, development of drug-resistance, resistance to second-line drugs, and alternative ways for TB treatment
Studies on the zoonotic aspect of bovine TB
Studies investigating social aspects of TB
These projects were conducted in collaboration with Belgian and international universities and research centers, as well as some non-governmental organizations. Research activities are currently conducted in Bangladesh, Cambodia, Georgia, Ethiopia and Peru, with a strong focus on drug resistance mechanisms.
In 2004, the Unit of Mycobacteriology obtained the ISO15189 accreditation for clinical laboratories and successfully maintained it thereafter under Leen Rigout’s leadership. Leen was actively involved in designing the new L2/L3 facilities for TB, and writing the respective biosafety guidelines. This expertise is now frequently consulted by international collaborating centers. She is member of various scientific expert committees like BELTA-TBnet and the New Diagnostic Working Group of the StopTB Partnership.
In 2011, part of the unit’s research collection became publically available through the ISO9001-certified BCCM/ITM mycobacterial culture collection, managed by Leen Rigouts.
Since 2008 she is professor in tropical infectious diseases at the University of Antwerp (UA), and from the start at ITM she was mentor of many bachelor and master student. Under her promotorship, two students have graduated as PhD, and about 6 are currently being supervised and guided.
Education/Academic qualification
Biological Sciences, PhD, Universiteit Gent
Tropical Medicine, Post-graduate, Institute of Tropical Medicine
Biological Sciences, Master, Universiteit Gent
External positions
Universiteit Antwerpen
1-Oct-2008 → …Keywords
- B110-medical-informatics
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Projects
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WGS-TB-DIAG: Whole Genome Sequencing to streamline TB diagnosis, improve TB surveillance and optimize individualized TB treatment a pragmatic trial
Van Rie, A., Rigouts, L., Callens, S., Warren, R. M., Beutels, P. & Janssens, N.
Fonds voor Wetenschappelijk Onderzoek
1/10/18 → 30/09/22
Project: Research Project
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TriDoRe: Novel High-Dose Tuberculosis Retreatment Regimens: How to overcome resistance without creating more?
Lynen, L., de Jong, B., Van Deun, A., Decroo, T., Gumusboga, M., Meehan, C., Lempens, P., Rigouts, L., Ratsarahery, L., Van Herrewege, Y., Buyze, J. & Herssens, N.
Flemish Government - Department of Economy, Science & Innovation
1/10/18 → 30/09/24
Project: Research Project
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PERU - FA4: To strengthen the R&D capacities of the Institute of Tropical Medicine Alexander von Humboldt (Peru) to deliver strategies and/or tools for diagnosis, surveillance and control of infectious diseases.
Dujardin, J., Rosanas-Urgell, A., de Jong, B., Ariën, K., Van der Auwera, G., Rigouts, L., Heyndrickx, L., Kattenberg, J. H., Battaglioli, T. C. E., Jacobs, J., Monsieurs, P. & Guetens, P.
1/11/17 → 31/12/21
Project: Development project
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DRC - FA4: Building capacity for health research in three DRC partner institutions Institut National de Recherche Biomédicale (IRNB), Ecole de Santé Publique de l’Université de Lubumbashi (ESP) en Centre de Recherche Sanitaire de Kimpese (CRS), and rationalize the fight against Human African Trypanosomiasis (HAT) while strengthening local health systems with the support of all partners.
Boelaert, M., Jacobs, J., Büscher, P., Polman, K., Rigouts, L., Dorny, P., Hardy, L., Corsmit, E., Roucher, C., Eddyani, M., Dermauw, V., Bebronne, N., Snijders, R., Inocêncio da Luz, R., Van Cauwenberg, I. & Everaert, R.
1/01/17 → 31/12/21
Project: Development project
Research output
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Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs
Jouet, A., Gaudin, C., Badalato, N., Allix-Béguec, C., Duthoy, S., Ferré, A., Diels, M., Laurent, Y., Contreras, S., Feuerriegel, S., Niemann, S., André, E., Kaswa, M. K., Tagliani, E., Cabibbe, A., Mathys, V., Cirillo, D., de Jong, B. C., Rigouts, L. & Supply, P., 2021, In : European Respiratory Journal. 57, 2Research output: Contribution to journal › A1: Web of Science-article
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An African origin for Mycobacterium bovis
Loiseau, C., Menardo, F., Aseffa, A., Hailu, E., Gumi, B., Ameni, G., Berg, S., Rigouts, L., Robbe-Austerman, S., Zinsstag, J., Gagneux, S. & Brites, D., 2020, In : Evolution, Medicine, and Public Health. 2020, 1, p. 49-59 11 p.Research output: Contribution to journal › A1: Web of Science-article
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A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region
Ngabonziza, J. C. S., Loiseau, C., Marceau, M., Jouet, A., Menardo, F., Tzfadia, O., Antoine, R., Niyigena, E. B., Mulders, W., Fissette, K., Diels, M., Gaudin, C., Duthoy, S., Ssengooba, W., André, E., Kaswa, M. K., Habimana, Y. M., Brites, D., Affolabi, D., Mazarati, J. B. & 5 others, , 2020, In : Nature Communications. 11, 1, p. 2917Research output: Contribution to journal › A1: Web of Science-article
Open AccessFile -
Broad diversity of Mycobacterium tuberculosis complex strains isolated from humans and cattle in Northern Algeria suggests a zoonotic transmission cycle
Damene, H., Tahir, D., Diels, M., Berber, A., Sahraoui, N. & Rigouts, L., 2020, In : PLoS Neglected Tropical Diseases. 14, 11, p. e0008894Research output: Contribution to journal › A1: Web of Science-article
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Case report: dynamics of acquired fluoroquinolone resistance under standardized short-course treatment of multidrug-resistant tuberculosis
Semuto Ngabonziza, J. C., Van Deun, A., Migambi, P., Belamo, N. E., Théogène, D., Habimana, Y. M., Ushizimpumu, B., Mulders, W., Decroo, T., Affolabi, D., Supply, P., de Jong, B. C. & Rigouts, L., 2020, In : American Journal of Tropical Medicine and Hygiene. 103, 4, p. 1443-1446 4 p.Research output: Contribution to journal › A1: Web of Science-article