Projects per year
Personal profile
Research expertise
Leen Rigouts graduated as a Master in Biological Science in 1987, and successfully completed a postgraduate course on Tropical Medicine (ITM) in 1988.
In 1989 she joined the Unit of Mycobacteriology at ITM, and executed various studies on serological diagnosis of tuberculosis (TB), identification of mycobacteria by fatty-acid analyses, and molecular epidemiology of bovine and human TB. The latter was the subject of her PhD thesis defended in 2000.
Since then she supervised and accomplished studies covering various aspects of human and bovine TB:
Molecular epidemiology studies on reinfection versus reactivation, prevalence of multiple M. tuberculosis infections, and transmission rates among MDR and non-MDR TB
Drug-resistance studies on its prevalence and incidence various geographic regions, rapid detection of drug resistance by molecular tools, development of drug-resistance, resistance to second-line drugs, and alternative ways for TB treatment
Studies on the zoonotic aspect of bovine TB
Studies investigating social aspects of TB
These projects were conducted in collaboration with Belgian and international universities and research centers, as well as some non-governmental organizations. Research activities are currently conducted in Bangladesh, Cambodia, Georgia, Ethiopia and Peru, with a strong focus on drug resistance mechanisms.
In 2004, the Unit of Mycobacteriology obtained the ISO15189 accreditation for clinical laboratories and successfully maintained it thereafter under Leen Rigout’s leadership. Leen was actively involved in designing the new L2/L3 facilities for TB, and writing the respective biosafety guidelines. This expertise is now frequently consulted by international collaborating centers. She is member of various scientific expert committees like BELTA-TBnet and the New Diagnostic Working Group of the StopTB Partnership.
In 2011, part of the unit’s research collection became publically available through the ISO9001-certified BCCM/ITM mycobacterial culture collection, managed by Leen Rigouts.
Since 2008 she is professor in tropical infectious diseases at the University of Antwerp (UA), and from the start at ITM she was mentor of many bachelor and master student. Under her promotorship, two students have graduated as PhD, and about 6 are currently being supervised and guided.
Education/Academic qualification
Biological Sciences, PhD, Ghent University
Award Date: 15-Jun-2000
Tropical Medicine, Post-graduate, Institute of Tropical Medicine
Award Date: 25-Mar-1988
Biological Sciences, Master, Ghent University
Award Date: 1-Sep-1987
External positions
University of Antwerp
1-Oct-2008 → …Keywords
- B110-medical-informatics
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Network
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Culturing from Tongue Swabs
Rigouts, L., de Jong, B., Hassane Harouna, S. & Janssens, N.
12/12/22 → 15/12/23
Project: Research Project
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TB/NTM Research Cluster
de Jong, B., Sengstake, S., Rigouts, L., Tzfadia, O., Ardizzoni, E., Lynen, L., Decroo, T., Hasker, E., Van Rie, A. & Janssens, N.
Fonds voor Wetenschappelijk Onderzoek
1/01/22 → 31/12/26
Project: Research Project
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BCCM: Consolidation and management of the BCCM Consortium as a "Belgian Research Center".
de Jong, B., Rigouts, L., Cogneau, S. & Janssens, N.
1/01/22 → 31/12/24
Project: Research Project
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InnoR3TB: Innovate to reduce rifampicin-resistant tuberculosis in Rwanda and beyond
de Jong, B., Rigouts, L., Mazarati, J. & Janssens, N.
1/01/21 → 31/12/24
Project: Research Project
Research output
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Acquired rifampicin resistance during first TB treatment: magnitude, relative importance, risk factors and keys to control in low-income settings
Van Deun, A., Bola, V., Lebeke, R., Kaswa, M., Hossain, M. A., Gumusboga, M., Torrea, G., De Jong, B. C., Rigouts, L. & Decroo, T., 2022, In: JAC-Antimicrobial Resistance. 4, 2, 9 p., dlac037.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Definitive outcomes in patients with rifampicin-resistant tuberculosis treated in Niger from 2012 to 2019: a retrospective cohort study
Souleymane, M. B., Decroo, T., Mamadou, S., Soumana, A., Lawan, I. M., Gagara-Issoufou, A., Adehossi, E., Ortuño-Gutiérrez, N., Lynen, L., Rigouts, L., de Jong, B. C., Van Deun, A. & Piubello, A., 2022, (E-pub ahead of print) In: International Health.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Distribution of common and rare genetic markers of second-line-injectable-drug resistance in Mycobacterium tuberculosis revealed by a genome-wide association study
Conkle-Gutierrez, D., Kim, C., Ramirez-Busby, S. M., Modlin, S. J., Mansjö, M., Werngren, J., Rigouts, L., Hoffner, S. E. & Valafar, F., 2022, In: Antimicrobial Agents and Chemotherapy. 66, 6, 12 p., e0207521.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
Marijke Braet, S., Jouet, A., Aubry, A., Van Dyck-Lippens, M., Lenoir, E., Assoumani, Y., Baco, A., Mzembaba, A., Cambau, E., Vasconcellos, S. E. G., Rigouts, L., Suffys, P. N., Hasker, E., Supply, P. & de Jong, B. C., 2022, In: Lancet Microbe. 3, 9, p. e693-e700 8 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Middlebrook 7H11 reduces invalid results and turnaround time of phenotypic drug susceptibility testing of M. tuberculosis
Rupasinghe, P., Vereecken, J., Decroo, T., Ardizzoni, E., Hewison, C., Huerga, H., Mesic, A., Rigouts, L. & de Jong, B., 2022.Research output: Contribution to conference › Poster