Projects per year
Personal profile
Research expertise
My research and main scientific motivation are driven by the fundamental challenge to uncover the link between genes and functions. I aspire filling the gaps in our current biological knowledge via application and implementation of computational algorithms tailored to handle big data. Most of the projects I am involved in are related to gene discovery for functional annotation.
Currently I am developing methods for omics data integration for discovery of drug-resistance-driver-mutations in Mycobacterium tuberculosis
During my career, I have developed several computational user-friendly tools aimed at utilizing omics data sets for biological discoveries.
An example of these tools includes:
•MORPH http://bioinformatics.psb.ugent.be/webtools/morphdb/morphDB/index/ is an algorithm designed to find candidate genes for specific metabolic pathways.
•MORPH.DB (http://bioinformatics.psb.ugent.be/webtools/coexpr/) a resource where MORPH-based candidate genes for large-scale functional annotations (Gene Ontology, MapMan bins) are integrated across multiple plant species.
•CoExpNetViz (http://bioinformatics.psb.ugent.be/webtools/coexpr/) is a tool for construction of co-expression networks (either in a single species or in a comparative transcriptomic manner).
•The hfAIM web-based tool (http://bioinformatics.psb.ugent.be/hfAIM/) can be used to effectively perform genome-wide in silico screens of proteins that are potentially regulated by selective autophagy.
•Cedalion, is a hypothesis generation platform that assists biologists with the interpretation of a newly sequenced genome (https://gitlab.psb.ugent.be/deep_genome/pipeline).
External positions
10%, Biomedical Informatics Research Network Antwerp (biomina), University of Antwerp, Antwerp, Belgium.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SNA_Leprosy: Improving leprosy prevention strategies by integrating social network analysis with spatial and molecular epidemiology data of Mycobacterium leprae in the Comoros
Peeters, K., Hasker, E., de Jong, B., Ronse, M., Verdonck, K., Braet, S., Tzfadia, O. & Everaert, R.
Flemish Government - Department of Economy, Science & Innovation
1/01/21 → 31/12/24
Project: Research Project
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Data integration to close the gap on Prediction of MTB Drug Resistance Mutations
de Jong, B., Tzfadia, O. & Janssens, N.
20/10/20 → 20/10/21
Project: Research Project
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Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century
Ngabonziza, J. C. S., Rigouts, L., Torrea, G., Decroo, T., Kamanzi, E., Lempens, P., Rucogoza, A., Habimana, Y. M., Laenen, L., Niyigena, B. E., Uwizeye, C., Ushizimpumu, B., Mulders, W., Ivan, E., Tzfadia, O., Muvunyi, C. M., Migambi, P., Andre, E., Mazarati, J. B., Affolabi, D. & 6 others, , 2022, In : Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 27, 100299.Research output: Contribution to journal › A1: Web of Science-article
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Corrigendum to: Siliplant1 protein precipitates silica in sorghum silica cells
Kumar, S., Adiram-Filiba, N., Blum, S., Sanchez-Lopez, J. A., Tzfadia, O., Omid, A., Volpin, H., Heifetz, Y., Goobes, G. & Elbaum, R., 2021, In : Journal of Experimental Medicine. 72, 18, p. 6672Research output: Contribution to journal › Article
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FASCICLIN-LIKE 18 is a new player regulating root elongation in Arabidopsis thaliana
Allelign Ashagre, H., Zaltzman, D., Idan-Molakandov, A., Romano, H., Tzfadia, O. & Harpaz-Saad, S., 2021, In : Frontiers in Plant Science. 12, 16 p., 645286.Research output: Contribution to journal › A1: Web of Science-article
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A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region
Ngabonziza, J. C. S., Loiseau, C., Marceau, M., Jouet, A., Menardo, F., Tzfadia, O., Antoine, R., Niyigena, E. B., Mulders, W., Fissette, K., Diels, M., Gaudin, C., Duthoy, S., Ssengooba, W., André, E., Kaswa, M. K., Habimana, Y. M., Brites, D., Affolabi, D., Mazarati, J. B. & 5 others, , 2020, In : Nature Communications. 11, 1, 11 p., 2917.Research output: Contribution to journal › A1: Web of Science-article
Open AccessFile11 Downloads (Pure) -
Biosynthesis and tissue-specific partitioning of camphor and eugenol in Ocimum kilimandscharicum
Singh, P., Kalunke, R. M., Shukla, A., Tzfadia, O., Thulasiram, H. V. & Giri, A. P., Sep-2020, In : Phytochemistry. 177, p. 112451Research output: Contribution to journal › Article