Projects per year
Personal profile
Research expertise
My research and main scientific motivation are driven by the fundamental challenge to uncover the link between genes and functions. I aspire filling the gaps in our current biological knowledge via application and implementation of computational algorithms tailored to handle big data. Most of the projects I am involved in are related to gene discovery for functional annotation.
During my career, I have developed several computational user-friendly tools aimed at utilizing omics data sets for biological discoveries.
An example of these tools includes:
Teaching expertise
Oren Tzfadia is dedicated to educating young scientists who wish to utilize bioinformatic tools for solving biological puzzles.
I teach:
- Introduction to Systems Biology
- Introduction to UNIX command line and WGS pipelines
- Introduction to AlphaFold and Protein Structural Analysis
I am also:
- Coaching master's students at ITM.
- Supervising PhD candidates at ITM and UA.
Education/Academic qualification
Bioinformatics
External positions
10%, University of Antwerp
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Collaborations and top research areas from the last five years
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IntegrOmicsDR: Multi Omics Data Integration to predict the M. tuberculosis Bedaquiline Resistance Phenotype from the Genotype
de Jong, B., Tzfadia, O. & de Jong, B.
1/01/22 → 31/12/25
Project: Research Project
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TB/NTM Cluster: TB/NTM Onderzoekscluster
de Jong, B., Sengstake, S., Rigouts, L., Tzfadia, O., Ardizzoni, E., Lynen, L., Decroo, T., Hasker, E., Van Rie, A., Lynen, L. & Hasker, E.
1/01/22 → 31/12/26
Project: Research Project
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SNA_Leprosy: Improving leprosy prevention strategies by integrating social network analysis with spatial and molecular epidemiology data of Mycobacterium leprae in the Comoros
Peeters, K., Hasker, E., de Jong, B., Ronse, M., Verdonck, T., Braet, S., Tzfadia, O., Ramanantsoa, A. & Peeters, K.
Flemish Government - Department of Economy, Science & Innovation
1/01/21 → 31/12/26
Project: Research Project
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Data integration to close the gap on Prediction of MTB Drug Resistance Mutations
de Jong, B., Tzfadia, O. & Janssens, N.
Flemish Government - Department of Economy, Science & Innovation
20/10/20 → 20/10/21
Project: Research Project
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Frameshift mutations in the mmpR5 gene can have a bedaquiline-susceptible phenotype by retaining a protein structure and function similar to wild-type Mycobacterium tuberculosis
Snobre, J., Meehan, CJ., Mulders, W., Rigouts, L., Buyl, R., de Jong, BC., Van Rie, A. & Tzfadia, O., 2024, (E-pub ahead of print) In: Antimicrobial Agents and Chemotherapy. 15 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open Access -
Single nucleotide variation catalog from clinical isolates mapped on tertiary and quaternary structures of ESX-1-related proteins reveals critical regions as putative Mtb therapeutic targets
Tzfadia, O., Gijsbers, A., Vujkovic, A., Snobre, J., Vargas, R., Dewaele, K., Meehan, CJ., Farhat, M., Hakke, S., Peters, PJ., de Jong, BC., Siroy, A. & Ravelli, RBG., 2024, (E-pub ahead of print) In: Microbiology Spectrum. 12, 8, 19 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open Access -
Volatile organic compound detection of Buruli ulcer disease: Headspace analysis of Mycobacterium ulcerans and used gauzes of Buruli-compatible ulcers
Chudy, SFJ., Phanzu, D. M., Kolk, AHJ., Sopoh, GE., Barogui, Y. T., Tzfadia, O., Eddyani, M., Fissette, K., de Jong, BC. & Brinkman, P., 2024, In: PLoS Neglected Tropical Diseases. 18, 9, 16 p., e0012514.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open Access -
Bedaquiline- and clofazimine- selected Mycobacterium tuberculosis mutants: further insights on resistance driven largely by Rv0678
Snobre, J., Villellas, M. C., Coeck, N., Mulders, W., Tzfadia, O., de Jong, B. C., Andries, K. & Rigouts, L., 2023, In: Scientific Reports. 13, 1, 11 p., 10444.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile26 Downloads (Pure) -
Transcriptome and metabolome profiling identify factors potentially involved in pro-vitamin A accumulation in cassava landraces
Olayide, P., Alexandersson, E., Tzfadia, O., Lenman, M., Gisel, A. & Stavolone, L., 2023, In: Plant Physiology and Biochemistry. 199, 12 p., 107713.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open Access