Oren Tzfadia

Oren Tzfadia

Dr., Senior Researcher Computational Biology

  • Nationalestraat 155

    2000 Antwerp


  • Nationalestraat

    2000 Antwerpen



Research activity per year

Personal profile

Research expertise

My research and main scientific motivation are driven by the fundamental challenge to uncover the link between genes and functions. I aspire filling the gaps in our current biological knowledge via application and implementation of computational algorithms tailored to handle big data. Most of the projects I am involved in are related to gene discovery for functional annotation.

Currently I am developing methods for omics data integration for discovery of drug-resistance-driver-mutations in Mycobacterium tuberculosis

During my career, I have developed several computational user-friendly tools aimed at utilizing omics data sets for biological discoveries.

An example of these tools includes:

•MORPH http://bioinformatics.psb.ugent.be/webtools/morphdb/morphDB/index/ is an algorithm designed to find candidate genes for specific metabolic pathways.
•MORPH.DB (http://bioinformatics.psb.ugent.be/webtools/coexpr/) a resource where MORPH-based candidate genes for large-scale functional annotations (Gene Ontology, MapMan bins) are integrated across multiple plant species.
•CoExpNetViz (http://bioinformatics.psb.ugent.be/webtools/coexpr/) is a tool for construction of co-expression networks (either in a single species or in a comparative transcriptomic manner).
•The hfAIM web-based tool (http://bioinformatics.psb.ugent.be/hfAIM/) can be used to effectively perform genome-wide in silico screens of proteins that are potentially regulated by selective autophagy.
•Cedalion, is a hypothesis generation platform that assists biologists with the interpretation of a newly sequenced genome (https://gitlab.psb.ugent.be/deep_genome/pipeline).

Teaching expertise

Oren Tzfadia is dedicated to educating young scientists who wish to utilize bioinformatic tools for solving biological puzzles.

I teach:

  • Introduction to Systems Biology
  • Introduction to UNIX command line and WGS pipelines
  • Introduction to AlphaFold and Protein Structural Analysis

I am also:

  • Coaching master's students at ITM.
  • Supervising PhD candidates at ITM and UA.

Education/Academic qualification


External positions

10%, University of Antwerp


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