Projects per year
Personal profile
Research expertise
My research and main scientific motivation are driven by the fundamental challenge to uncover the link between genes and functions. I aspire filling the gaps in our current biological knowledge via application and implementation of computational algorithms tailored to handle big data. Most of the projects I am involved in are related to gene discovery for functional annotation.
Currently I am developing methods for omics data integration for discovery of drug-resistance-driver-mutations in Mycobacterium tuberculosis
During my career, I have developed several computational user-friendly tools aimed at utilizing omics data sets for biological discoveries.
An example of these tools includes:
•MORPH http://bioinformatics.psb.ugent.be/webtools/morphdb/morphDB/index/ is an algorithm designed to find candidate genes for specific metabolic pathways.
•MORPH.DB (http://bioinformatics.psb.ugent.be/webtools/coexpr/) a resource where MORPH-based candidate genes for large-scale functional annotations (Gene Ontology, MapMan bins) are integrated across multiple plant species.
•CoExpNetViz (http://bioinformatics.psb.ugent.be/webtools/coexpr/) is a tool for construction of co-expression networks (either in a single species or in a comparative transcriptomic manner).
•The hfAIM web-based tool (http://bioinformatics.psb.ugent.be/hfAIM/) can be used to effectively perform genome-wide in silico screens of proteins that are potentially regulated by selective autophagy.
•Cedalion, is a hypothesis generation platform that assists biologists with the interpretation of a newly sequenced genome (https://gitlab.psb.ugent.be/deep_genome/pipeline).
External positions
10%, University of Antwerp
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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IntegrOmicsDR.MTB: Multi Omics Data Integration to predict the M. tuberculosis Bedaquiline Resistance Phenotype from the Genotype
de Jong, B., Tzfadia, O. & Janssens, N.
1/01/22 → 31/12/25
Project: Research Project
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TB/NTM Research Cluster
de Jong, B., Sengstake, S., Rigouts, L., Tzfadia, O., Ardizzoni, E., Lynen, L., Decroo, T., Hasker, E., Van Rie, A. & Janssens, N.
1/01/22 → 31/12/26
Project: Research Project
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SNA_Leprosy: Improving leprosy prevention strategies by integrating social network analysis with spatial and molecular epidemiology data of Mycobacterium leprae in the Comoros
Peeters, K., Hasker, E., de Jong, B., Ronse, M., Verdonck, T., Braet, S., Tzfadia, O., Everaert, R. & Ramanantsoa, A.
Flemish Government - Department of Economy, Science & Innovation
1/01/21 → 31/12/24
Project: Research Project
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Data integration to close the gap on Prediction of MTB Drug Resistance Mutations
de Jong, B., Tzfadia, O. & Janssens, N.
Flemish Government - Department of Economy, Science & Innovation
20/10/20 → 20/10/21
Project: Research Project
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Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century
Ngabonziza, J. C. S., Rigouts, L., Torrea, G., Decroo, T., Kamanzi, E., Lempens, P., Rucogoza, A., Habimana, Y. M., Laenen, L., Niyigena, B. E., Uwizeye, C., Ushizimpumu, B., Mulders, W., Ivan, E., Tzfadia, O., Muvunyi, C. M., Migambi, P., Andre, E., Mazarati, J. B., Affolabi, D. & 6 others, , 2022, In: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 27, 100299.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile3 Downloads (Pure) -
Corrigendum to: Siliplant1 protein precipitates silica in sorghum silica cells
Kumar, S., Adiram-Filiba, N., Blum, S., Sanchez-Lopez, J. A., Tzfadia, O., Omid, A., Volpin, H., Heifetz, Y., Goobes, G. & Elbaum, R., 2021, In: Journal of Experimental Medicine. 72, 18, 6672.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile4 Downloads (Pure) -
FASCICLIN-LIKE 18 is a new player regulating root elongation in Arabidopsis thaliana
Allelign Ashagre, H., Zaltzman, D., Idan-Molakandov, A., Romano, H., Tzfadia, O. & Harpaz-Saad, S., 2021, In: Frontiers in Plant Science. 12, 16 p., 645286.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile5 Downloads (Pure) -
A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region
Ngabonziza, J. C. S., Loiseau, C., Marceau, M., Jouet, A., Menardo, F., Tzfadia, O., Antoine, R., Niyigena, E. B., Mulders, W., Fissette, K., Diels, M., Gaudin, C., Duthoy, S., Ssengooba, W., André, E., Kaswa, M. K., Habimana, Y. M., Brites, D., Affolabi, D., Mazarati, J. B. & 5 others, , 2020, In: Nature Communications. 11, 1, 11 p., 2917.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile21 Downloads (Pure) -
Biosynthesis and tissue-specific partitioning of camphor and eugenol in Ocimum kilimandscharicum
Singh, P., Kalunke, R. M., Shukla, A., Tzfadia, O., Thulasiram, H. V. & Giri, A. P., 2020, In: Phytochemistry. 177, 112451.Research output: Contribution to journal › A1: Web of Science-article › peer-review