Saskia Decuypere

Research output

Research output per year 2003 2005 2007 2009 2010 2011 2012 2013 2016 2016

• 30 A1: Web of Science-article
• 3 Chapter
• 1 A2: International peer reviewed article (not A1-type)
• 1 Doctoral dissertation - Doctoral dissertation

Research output per year

Research output per year

Search results

• 2016

  Diagnosis of bacterial bloodstream infections: a 16S metagenomics approach

  Decuypere, S., Meehan, C. J., Van Puyvelde, S., De Block, T., Maltha, J., Palpouguini, L., Tahita, M., Tinto, H., Jacobs, J. & Deborggraeve, S., 2016, In: PLoS Neglected Tropical Diseases. 10, 2, 12 p., e0004470.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  Open Access

  File

  • illness 32%
  • Environmental contamination 30%
  • hospital admission 28%
  • Burkina Faso 25%
  • cause of death 22%
  143 Downloads (Pure)

• Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

  Imamura, H., Downing, T., Van den Broeck, F., Sanders, M. J., Rijal, S., Sundar, S., Mannaert, A., Vanaerschot, M., Berg, M., De Muylder, G., Dumetz, F., Cuypers, B., Maes, I., Domagalska, M., Decuypere, S., Rai, K., Uranw, S., Bhattarai, N. R., Khanal, B., Prajapati, V. K., & 13 othersSharma, S., Stark, O., Schönian, G., De Koning, H. P., Settimo, L., Vanhollebeke, B., Roy, S., Ostyn, B., Boelaert, M., Maes, L., Berriman, M., Dujardin, J-C. & Cotton, J. A., 2016, In: eLIFE. 5, 39 p., e12613.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  Open Access

  File

  • Leishmania donovani 100%
  • Visceral Leishmaniasis 90%
  • Parasitic 45%
  • Drug 38%
  • Vector Borne Diseases 34%
  101 Downloads (Pure)

• Towards improving point-of-care diagnosis of non-malaria febrile illness: a metabolomics approach

  Decuypere, S., Maltha, J., Deborggraeve, S., Rattray, N. J. W., Issa, G., Bérenger, K., Lompo, P., Tahita, M. C., Ruspasinghe, T., McConville, M., Goodacre, R., Tinto, H., Jacobs, J. & Carapetis, J. R., 2016, In: PLoS Neglected Tropical Diseases. 10, 3, 19 p., e0004480.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  Open Access

  File

  • illness 100%
  • Infections 52%
  • tropics 25%
  • clinical outcomes 24%
  • diagnostic test 22%
  56 Downloads (Pure)
• 2013

  Drug-resistant microorganisms with a higher fitness - can medicines boost pathogens?

  Vanaerschot, M., Decuypere, S., Berg, M., Roy, S. & Dujardin, J. C., 2013, In: Critical Reviews in Microbiology. 39, 4, p. 384-394 11 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Pharmaceutical Preparations 100%
  • Immune System 54%
  • Leishmania donovani 46%
  • Parasites 28%

• Increasing failure of miltefosine in the treatment of kala-azar in Nepal and the potential role of parasite drug resistance, re-infection or non-compliance

  Rijal, S., Ostyn, B., Uranw, S., Rai, K., Bhattarai, N. R., Dorlo, T. P., Beijnen, J. H., Vanaerschot, M., Decuypere, S., Dhakal, S. S., Das, M. L., Karki, P., Singh, R., Boelaert, M. & Dujardin, J. C., 2013, In: Clinical Infectious Diseases. 56, 11, p. 1530-1538 9 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • miltefosine 100%
  • Nepal 82%
  • Visceral Leishmaniasis 81%
  • Drug Resistance 60%
  • Parasites 54%
• 2012

  Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent

  Vanaerschot, M., Decuypere, S., Downing, T., Imamura, H., Stark, O., De Doncker, S., Roy, S., Ostyn, B., Maes, L., Khanal, B., Boelaert, M., Schönian, G., Berriman, M., Chappuis, F., Dujardin, J. C., Sundar, S. & Rijal, S., 2012, In: Journal of Infectious Diseases. 206, 5, p. 752-755 4 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Leishmania donovani 100%
  • Visceral Leishmaniasis 90%
  • Genetic Markers 77%
  • Treatment Failure 71%
  • Parasites 61%

• Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex

  Downing, T., Stark, O., Vanaerschot, M., Imamura, H., Sanders, M., Decuypere, S., De Doncker, S., Maes, I., Rijal, S., Sundar, S., Dujardin, JC., Berriman, M. & Schönian, G., 2012, In: Infection, Genetics and Evolution. 12, 1, p. 149-159

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Leishmania donovani 100%
  • species complex 97%
  • epidemiology 81%
  • parasite 74%
  • genome 69%

• Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background

  Decuypere, S., Vanaerschot, M., Brunker, K., Imamura, H., Müller, S., Khanal, B., Rijal, S., Dujardin, JC. & Coombs, GH., 2012, In: PLoS Neglected Tropical Diseases. 6, 2, p. e1514

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  Open Access

  File
  41 Downloads (Pure)
• 2011

  Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden

  Vanaerschot, M., De Doncker, S., Rijal, S., Maes, L., Dujardin, JC. & Decuypere, S., 2011, In: PLoS ONE. 6, 8, p. e23120 5 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  File

  • miltefosine 100%
  • Leishmania donovani 89%
  • Parasites 54%
  • Visceral Leishmaniasis 34%
  • Virulence 8%
  22 Downloads (Pure)

• Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells

  Mukhopadhyay, R., Mukherjee, S., Mukherjee, B., Naskar, K., Mondal, D., Decuypere, S., Ostyn, B., Prajapati, VK., Sundar, S., Dujardin, JC. & Roy, S., 2011, In: International Journal for Parasitology. 41, 13-14, p. 1311-21

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Leishmania donovani 100%
  • Membrane Fluidity 31%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 27%
  • Interleukin-10 21%
  • Parasites 20%

• Comparative gene expression analysis throughout the life cycle of Leishmania braziliensis: diversity of expression profiles among clinical isolates

  Adaui, V., Castillo, D., Zimic, M., Gutierrez, A., Decuypere, S., Vanaerschot, M., De Doncker, S., Schnorbusch, K., Maes, I., Van der Auwera, G., Maes, L., Llanos-Cuentas, A., Arevalo, J. & Dujardin, JC., 2011, In: PLoS Neglected Tropical Diseases. 5, 5, p. e1021

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  File

  • Leishmania braziliensis 100%
  • life cycle 65%
  • regulation 38%
  • time 22%
  • methodology 16%
  29 Downloads (Pure)

• Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony

  Adaui, V., Schnorbusch, K., Zimic, M., Gutiérrez, A., Decuypere, S., Vanaerschot, M., De Doncker, S., Maes, I., Llanos-Cuentas, A., Chappuis, F., Arévalo, J. & Dujardin, JC., 2011, In: Parasitology. 138, 2, p. 183-193 11 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  File

  • Leishmania braziliensis 100%
  • trypanothione reductase 23%
  • Parasites 21%
  • Housekeeping 17%
  • Ornithine Decarboxylase 16%
  35 Downloads (Pure)

• Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines

  Ouakad, M., Vanaerschot, M., Rijal, S., Sundar, S., Speybroeck, N., Kestens, L., Boel, L., De Doncker, S., Maes, I., Decuypere, S. & Dujardin, JC., 2011, In: Parasitology. 138, 11, p. 1392-1399

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  File

  • Leishmania donovani 100%
  • Pharmaceutical Preparations 30%
  • Gene Expression Profiling 19%
  • Microscopy 15%
  • Theoretical Models 15%
  61 Downloads (Pure)

• Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

  Downing, T., Imamura, H., Decuypere, S., Clark, TG., Coombs, GH., Cotton, JA., Hilley, JD., De Doncker, S., Maes, I., Mottram, JC., Quail, MA., Rijal, S., Sanders, M., Schönian, G., Stark, O., Sundar, S., Vanaerschot, M., Hertz-Fowler, C., Dujardin, JC. & Berriman, M., 2011, In: Genome Research. 21, 12, p. 2143-2156

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  File

  • Leishmania donovani 100%
  • Visceral Leishmaniasis 67%
  • Drug Resistance 67%
  • Endemic Diseases 24%
  • Nepal 22%
  52 Downloads (Pure)
• 2010

  Linking in vitro and in vivo survival of clinical Leishmania donovani strains

  Vanaerschot, M., Maes, I., Ouakad, M., Adaui, V., Maes, L., De Doncker, S., Rijal, S., Chappuis, F., Dujardin, JC. & Decuypere, S., 2010, In: PLoS ONE. 5, 8, p. e12211 9 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Leishmania donovani 100%
  • Parasites 61%
  • Visceral Leishmaniasis 18%
  • Infections 14%
  • Drug Resistance 13%

• Metabolomics to unveil and understand phenotypic diversity between pathogen populations

  t`Kindt, R., Scheltema, RA., Jankevics, A., Brunker, K., Rijal, S., Dujardin, JC., Breitling, R., Watson, DG., Coombs, GH. & Decuypere, S., 2010, In: PLoS Neglected Tropical Diseases. 4, 11, p. e904 12 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • drug 100%
  • Parasites 81%
  • Leishmania donovani 66%
  • Pharmaceutical Preparations 61%
  • Nepal 20%

• Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry

  Zheng, L., t`Kindt, R., Decuypere, S., von Freyend, SJ., Coombs, GH. & Watson, DG., 2010, In: Rapid Communications in Mass Spectrometry. 24, 14, p. 2074-2082 9 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • FT/ICR Mass Spectrometry 100%
  • Chromatography 67%
  • Lipid 60%
  • Lysophosphatidylcholine 34%
  • Sphingosine 33%

• The potential of metabolomics for Leishmania research in the post-genomics era

  Scheltema, RA., Decuypere, S., t`Kindt, R., Dujardin, JC., Coombs, GH. & Breitling, R., 2010, In: Parasitology. 137, 9, p. 1291-1302 12 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Leishmania donovani 100%
  • Computational Biology 69%
  • Pharmaceutical Preparations 61%

• Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

  t`Kindt, R., Jankevics, A., Scheltema, RA., Zheng, L., Watson, DG., Dujardin, JC., Breitling, R., Coombs, GH. & Decuypere, S., 2010, In: Analytical and Bioanalytical Chemistry. 398, 5, p. 2059-2069 11 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Parasites 100%
  • Sampling 99%
  • Metabolic 97%
  • Metabolite 84%
  • Liquid Chromatography 31%
• 2009

  Immunological determinants of clinical outcome in Peruvian patients with tegumentary leishmaniasis treated with pentavalent antimonials

  Maurer-Cecchini, A., Decuypere, S., Chappuis, F., Alexandrenne, C., De Doncker, S., Boelaert, M., Dujardin, JC., Loutan, L., Dayer, JM., Tulliano, G., Arevalo, J., Llanos-Cuentas, A. & Chizzolini, C., 2009, In: Infection and Immunity. 77, 5, p. 2022-2029 8 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

• Simple data-reduction method for high-resolution LC-MS data in metabolomics

  Scheltema, RA., Decuypere, S., Dujardin, JC., Watson, DG., Jansen, RC. & Breitling, R., 2009, In: Bioanalysis. 1, 9, p. 1551-1557 7 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

  • Filtration 100%
  • Leishmania donovani 78%
  • Databases 69%
  • Percent Reduction 67%
  • Isotopes 62%
• 2008

  Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation

  Decuypere, S., Vanaerschot, M., Rijal, S., Yardley, V., Maes, L., De Doncker, S., Chappuis, F. & Dujardin, JC., 2008, In: Parasitology. 135, 2, p. 183-194 12 p.

  Research output: Contribution to journal › A1: Web of Science-article › peer-review
• 2007

  Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome?

  Rijal, S., Yardley, V., Chappuis, F., Decuypere, S., Khanal, B., Singh, R., Boelaert, M., De Doncker, S., Croft, S. & Dujardin, JC., 2007, In: Microbes and Infection. 9, 4, p. 529-535

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

• Epidemiological dynamics of antimonial resistance in Leishmania donovani; genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal

  Laurent, T., Rijal, S., Yardley, V., Croft, S., De Doncker, S., Decuypere, S., Khanal, B., Singh, R., Schönian, G., Kuhls, K., Chappuis, F. & Dujardin, JC., 2007, In: Infection, Genetics and Evolution. 7, 2, p. 206-212

  Research output: Contribution to journal › A1: Web of Science-article › peer-review
• 2006

  American tegumentary leishmaniasis: is antimonial treatment outcome related to parasite drug susceptibility?

  Yardley, V., Ortuño, N., Llanos-Cuentas, A., Chappuis, F., De Doncker, S., Ramirez, L., Croft, S., Arevalo, J., Adaui, V., Bermudez, H., Decuypere, S. & Dujardin, JC., 2006, In: Journal of Infectious Diseases. 194, 8, p. 1168-1175

  Research output: Contribution to journal › A1: Web of Science-article › peer-review
• 2005

  A new PCR-ELISA for diagnosis of visceral leishmaniasis in blood of HIV-negative subjects

  De Doncker, S., Hutse, V., Abdellati, S., Rijal, S., Karki, BMS., Decuypere, S., Jacquet, D., Le Ray, D., Boelaert, M., Koirala, S. & Dujardin, JC., 2005, In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 99, 1, p. 25-31

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

• Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania

  Decuypere, S., Vandesompele, J., Yardley, V., De Doncker, S., Laurent, T., Rijal, S., Llanos-Cuentas, A., Chappuis, F., Arevalo, J. & Dujardin, JC., 2005, In: Parasitology. 131, 3, p. 321-329

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

• Fluorogenic assay for molecular typing of the Leishmania donovani complex: taxonomic and clinical applications

  Quispe Tintaya, KW., Laurent, T., Decuypere, S., Hide, M., Bañuls, AL., De Doncker, S., Rijal, S., Canavate, C., Campino, L. & Dujardin, JC., 2005, In: Journal of Infectious Diseases. 192, 4, p. 685-692

  Research output: Contribution to journal › A1: Web of Science-article › peer-review

• Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal

  Decuypere, S., Rijal, S., Yardley, V., De Doncker, S., Laurent, T., Khanal, B., Chappuis, F. & Dujardin, JC., 2005, In: Antimicrobial Agents and Chemotherapy. 49, 11, p. 4616-4621

  Research output: Contribution to journal › A1: Web of Science-article › peer-review
• 2003

  Pathogen genotyping in polyclonal infections: application of a fluorogenic polymerase-chain-reaction assay in malaria

  Decuypere, S., Elinck, E., Van Overmeir, C., Talisuna, AO., D'Alessandro, U. & Dujardin, JC., 2003, In: Journal of Infectious Diseases. 188, 8, p. 1245-1249

  Research output: Contribution to journal › A1: Web of Science-article › peer-review