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Sheeba Santhini Basil earned her Master's (M.Sc and M.Phil) in Microbiology from India. Before heading to the University of Iceland (UI) for her Ph. D, she worked as a lecturer in India, teaching molecular biology, microbiology, and bioinformatics. She pursued her doctoral studies in collaboration with the University of British Columbia, Canada, while teaching lab courses at UI (Methods in molecular biology, genomics, genetics and bioinformatics -2013). She obtained her PhD in Biology with specializations in molecular genetics and bioinformatics (https://english.hi.is/events/ doctoral_defence_in_biology_sheeba_santhini_basil). She sought to understand the mechanisms of symbiosis in the lichen Peltigera membranacea by using DNA-Seq, RNA-Seq and BS-Seq that were used to characterize the genome, tissue-specific transcriptomes and methylomes of the lichen, respectively. In addition, she discovered a new lichen Peltigera islandica.
Before joining the Institute of Tropical Medicine, she worked as a post-doctoral researcher at the Department of Plant Genetics, University of Liege, and characterized the clonal transcriptome of Chlamydomonas reinhardtii using an unbiased thermodynamic maximal-entropy-based approach (surprisal analysis).
Sheeba joined the unit of Prof. Chris Kenyon as a Scientific Fellow to investigate the genotypic and phenotypic diversity of the pathogen Neisseria gonorrhoeae and dissect the interaction of the pathogen with the commensal bacterium in different niches. She continues to study antimicrobial resistance and horizontal gene transfer in Neisseria spp. using various methods, including genomics, transcriptomics, shotgun metagenomics, and molecular microbiology approaches.
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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PRESTIP: PReventing the Emergence of untreatable STIs via radical Prevention
Kenyon, C., Crucitti, T., De Baetselier, I., Florence, E., Soentjens, P., Basil, S. S. & Kenyon, C.
Flemish Government - Department of Economy, Science & Innovation
1/01/21 → 31/12/24
Project: Research Project
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Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP
Kenyon, C., Gestels, Z., Vanbaelen, T., Abdellati, S., Van Den Bossche, D., De Baetselier, I., Xavier, B. B. & Manoharan-Basil, S. S., 2023, In: Frontiers in Microbiology. 14, 8 p., 1208014.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile -
Doxycycline Post Exposure Prophylaxis could induce cross-resistance to other classes of antimicrobials in Neisseria gonorrhoeae: an in-silico analysis
Vanbaelen, T., Manoharan-Basil, S. S. & Kenyon, C., 2023, In: Sexually Transmitted Diseases. 50, 8, p. 490-493 4 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Doxycycline post exposure prophylaxis could select for cross-resistance to other antimicrobials in various pathogens: an in silico analysis
Gestels, Z., Manoharan-Basil, S. S. & Kenyon, C., 19-Jul-2023, (E-pub ahead of print) In: International Journal of STD & AIDS. 9564624231190108.Research output: Contribution to journal › A1: Web of Science-article › peer-review
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Enolase is implicated in the emergence of gonococcal tolerance to ceftriaxone
Manoharan-Basil, S. S., Balduck, M., Abdellati, S., Gestels, Z., de Block, T. & Kenyon, C., 2023, In: Antibiotics-Basel. 12, 3, p. 534 7 p.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile97 Downloads (Pure) -
Evidence of horizontal gene transfer within porB in 19 018 whole-genome Neisseria spp. isolates: a global phylogenetic analysis
Manoharan-Basil, S. S., Gestels, Z., Abdellati, S., Akomoneh, E. A. & Kenyon, C., 2023, In: Microbial Genomics. 9, 6, 001041.Research output: Contribution to journal › A1: Web of Science-article › peer-review
Open AccessFile40 Downloads (Pure)