Project Details
Description
Main Objective is to assess the safety and efficacy of three artemesinin-based combination therapies (ACTs) (mefloquine-artesunate, dihydroartemisinin-piperaquine and artemetherlumefantrine) for the treatment of malaria in Zambian pregnant women. This study will be done in Nchelenge district of Luapula province, Zambia.
Specific Objectives:
1. To characterise the malaria endemicity in Nchelenge district;
2. To determine the safety and efficacy of mefloquine-artesunate, dihydroartemisininpiperaquine and artemether-lumefantrine in treating pregnant women with a P. falciparum malaria infection;
3. To compare the impact of the three treatments on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant;
4. To determine the relationship between drug levels (partner drug) at day 7 and response to treatment;
5. To determine the impact of malaria preventive measures as IPT, ITN and ACT treatment on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant.
Specific Objectives:
1. To characterise the malaria endemicity in Nchelenge district;
2. To determine the safety and efficacy of mefloquine-artesunate, dihydroartemisininpiperaquine and artemether-lumefantrine in treating pregnant women with a P. falciparum malaria infection;
3. To compare the impact of the three treatments on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant;
4. To determine the relationship between drug levels (partner drug) at day 7 and response to treatment;
5. To determine the impact of malaria preventive measures as IPT, ITN and ACT treatment on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant.
| Status | Finished |
|---|---|
| Effective start/end date | 1/11/09 → 20/12/19 |
IWETO expertise domain
- B780-tropical-medicine