Antimalarial treatment efficacy and safety in pregnant women

  • Nambozi, Michael, (PhD Student)
  • D'Alessandro, Umberto, (Promotor)
  • Van Geertruyden, Jean-Pierre (Promotor)
  • Mulenga, Modest (Promotor)

    Project Details

    Description

    Main Objective is to assess the safety and efficacy of three artemesinin-based combination therapies (ACTs) (mefloquine-artesunate, dihydroartemisinin-piperaquine and artemetherlumefantrine) for the treatment of malaria in Zambian pregnant women. This study will be done in Nchelenge district of Luapula province, Zambia.
    Specific Objectives:
    1. To characterise the malaria endemicity in Nchelenge district;
    2. To determine the safety and efficacy of mefloquine-artesunate, dihydroartemisininpiperaquine and artemether-lumefantrine in treating pregnant women with a P. falciparum malaria infection;
    3. To compare the impact of the three treatments on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant;
    4. To determine the relationship between drug levels (partner drug) at day 7 and response to treatment;
    5. To determine the impact of malaria preventive measures as IPT, ITN and ACT treatment on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant.
    StatusFinished
    Effective start/end date1/11/0920/12/19

    IWETO expertise domain

    • B780-tropical-medicine