FasciCoM-Emergence of fascioliasis in a global setting: development and validation of a transmission model to identify cost-effective control strategies

Project Details

Layman's description

Fascioliasis is a parasitic disease caused by the zoonotic worm
species Fasciola hepatica and F. gigantica. This disease affects the
liver of mammalian hosts and is primarily known for its high burden
and associated economic impact in livestock. However, during the
last decades, fascioliasis has also become an emerging problem for
public health. Today, 2.4 million people are estimated to be infected,
and over 180 million people at risk in over 70 countries, including
Vietnam. Despite the zoonotic nature of the disease, current control
programmes use an exclusively human-centric approach. We
hypothesise that to interrupt the disease transmission, a One Health
approach is needed. To this end, we will develop the first disease
transmission model for Fasciola that includes all four actors of the
transmission cycle (humans, livestock, snails and water plants). We
will calibrate and validate the model in a Vietnamese setting, where
the emergence of fascioliasis has taken worrying proportions. To this
end, we will collect Fasciola prevalence, socio-demographic and
behavioural data in the Red River Delta to parameterize the model.
In addition, we will assess the health and economic burden of
fascioliasis in Vietnam. This model will be used to identify in silico the
most cost-effective control strategies. Finally, we will translate the
Vietnamese model to a general disease transmission model that will
allow identification of the most feasible strategy in any scenario of
endemicity.
StatusActive
Effective start/end date1/01/2131/12/23

Funding

  • Fonds voor Wetenschappelijk Onderzoek: €97,050.00

Flemish disciplinelist

  • Veterinary public health and food safety