In vivo mRNA delivery into dendritic cells for immunotherapy

  • Vanham, Guido (Promotor)
  • Grooten, Johan (Copromotor)
  • De Smedt, Stefaan (Copromotor)
  • Rejman, J (Copromotor)
  • Van Gulck, Ellen (Researcher)
  • Janssens, Nancy (Administrator)

Project Details

Description

In this project we want to develop new non-viral carriers for mRNA that are ultimately intended for immunotherapeutic purposes. The objective of this project is to (1) develop nanoparticle carriers for HIV Gag mRNA delivery to dendritic cells, (2) follow the intracellular fate of the mRNA-carrier complex, (3) improve the antigen presenting capacity of the complex, (4) Evaluate the induction of T cell responses in mice.
AcronymHIV mRNA
StatusFinished
Effective start/end date1/01/10 → 31/12/15

Funding

  • Research Fund - Flanders: €80,500.00