Inhibition of human immunodeficiency virus (HIV) replication

  • Vanham, Guido (Promotor)
  • VERHASSELT, Bruno (Partner)
  • MOUTSCHEN, Michel (Partner)
  • BERNEMAN, Zwi (Partner)
  • VANDAMME, Anne-Mieke (Partner)
  • BERKHOUT, Ben (Partner)

Project Details



The effective inhibition of HIV replication targeting viral escape and resistance under immune and drug pressure.


In silico: to genotype HIV drug resistance interpretation and predict HIV evolution with applied and optimalized resistance algorithms and fitness models as bio-informatics tools.In vitro: to study new therapeutic HIV targets, siRNA manipulation and gene therapy, and the induction of anti-HIV cellular immune responses using normal donor and patients' blood cells and viral strains.In vivo: to test the experimental immunological in vitro findings on relevance and/or efficiency in a Trimera mouse HIV model.
AcronymHIV Control
Effective start/end date1/01/0731/03/12


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