Spatial analysis of host-parasite interactions in the skin across the clinical spectrum of cutaneous leishmaniasis in Ethiopia

Project Details

Description

Cutaneous leishmaniasis manifestations range from self-healing localized skin ulcers/nodules to diffusely spread chronic lesions. Knowledge on the host-parasite interactions underpinning the different clinical presentations is scarce, in particular for L. aethiopica infections where disease can be extremely severe. To generate unprecedented insights into the host-parasite interplay within the skin, we propose a first-in-its-kind and in-depth in situ evaluation of the immune and metabolic environment at the site of parasitism, combining host and parasite spatial RNA/protein profiling and mass spectrometry imaging. This research will provide novel insights into skin immunity and identify targets for prevention and treatment of leishmaniasis.

Description

Cutaneous leishmaniasis manifestations range from self-healing localized skin ulcers/nodules to diffusely spread chronic lesions. Knowledge on the host-parasite interactions underpinning the different clinical presentations is scarce, in particular for L. aethiopica infections where disease can be extremely severe. To generate unprecedented insights into the host-parasite interplay within the skin, we propose a first-in-its-kind and in-depth in situ evaluation of the immune and metabolic environment at the site of parasitism, combining host and parasite spatial RNA/protein profiling and mass spectrometry imaging. This research will provide novel insights into skin immunity and identify targets for prevention and treatment of leishmaniasis.
AcronymSpatialCL
StatusActive
Effective start/end date1/01/2131/12/24

Funding

  • Dioraphte Foundation: €850,000.00

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