1912-2012: a century of research on Plasmodium vivax in vitro culture

F. Noulin, C. Borlon, J. Van Den Abbeele, Umberto D'Alessandro, A. Erhart

Research output: Contribution to journalA1: Web of Science-articlepeer-review


The development of a continuous Plasmodium vivax blood cycle in vitro was first attempted 100 years ago. Since then, and despite the use of different methods, only short-term cultures have been achieved so far. The available literature has been reviewed in order to provide a critical overview of the currently available knowledge on P. vivax blood cycle culture systems and identify some unexplored ways forward. Results show that data accumulated over the past century remain fragmented and often contradictory, making it difficult to draw conclusions. There is the need for an international consortium on P. vivax culture able to collect, update, and share new evidence, including negative results, and thus better coordinate current efforts towards the establishment of a continuous P. vivax culture.
Original languageEnglish
JournalTrends In Parasitology
Issue number6
Pages (from-to)286-294
Number of pages9
Publication statusPublished - 2013


  • Protozoal diseases
  • Malaria
  • Plasmodium vivax
  • Vectors
  • Mosquitoes
  • Anopheles
  • Research
  • History
  • Culture techniques
  • In vitro
  • Life cycles
  • Erythrocytes
  • Staging
  • Protocols
  • Blood
  • Systematic review
  • Review of the literature

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