A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis

S. de Worm; J. B. Giot; C. Courtoy; E. Gillet; Sophie Amrane; P. Huynen; M. Van Esbroeck; E. Prudent; H. Lepidi; Matthieu Million; M. Moutschen; Didier Raoult

doi:10.1016/j.ijid.2018.01.028

A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis

S. de Worm, J. B. Giot, C. Courtoy, E. Gillet, Sophie Amrane, P. Huynen, M. Van Esbroeck, E. Prudent, H. Lepidi, Matthieu Million, M. Moutschen, Didier Raoult

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Abstract

A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen on F-18-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Given the aneurysm of the abdominal aorta, the patient underwent replacement of the abdominal aorta with an allograft. Histology showed intense chronic arteritis attributed to atherosclerosis with dissection. However, Coxiella burnetii infection was confirmed by serology and then by culture and molecular biology on the surgical specimen. A combination of hydroxychloroquine and doxycycline was added to tapered prednisolone and the outcome was favourable. (c) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.

Original language	English
Journal	International Journal of Infectious Diseases
Volume	69
Pages (from-to)	50-54
Number of pages	5
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2018.01.028
Publication status	Published - 2018

Keywords

Coxiella burnetii
Giant cell arteritis
Aortitis
Q fever
Vascular infection
ACUTE Q-FEVER
INFECTION
VASCULOPATHY
DIAGNOSIS
PATIENT

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2018ijid0050Final published version, 1.17 MBLicence: Unspecified

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title = "A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis",

abstract = "A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen on F-18-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Given the aneurysm of the abdominal aorta, the patient underwent replacement of the abdominal aorta with an allograft. Histology showed intense chronic arteritis attributed to atherosclerosis with dissection. However, Coxiella burnetii infection was confirmed by serology and then by culture and molecular biology on the surgical specimen. A combination of hydroxychloroquine and doxycycline was added to tapered prednisolone and the outcome was favourable. (c) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.",

keywords = "Coxiella burnetii, Giant cell arteritis, Aortitis, Q fever, Vascular infection, ACUTE Q-FEVER, INFECTION, VASCULOPATHY, DIAGNOSIS, PATIENT",

author = "{de Worm}, S. and Giot, {J. B.} and C. Courtoy and E. Gillet and Sophie Amrane and P. Huynen and {Van Esbroeck}, M. and E. Prudent and H. Lepidi and Matthieu Million and M. Moutschen and Didier Raoult",

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T1 - A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis

AU - de Worm, S.

AU - Giot, J. B.

AU - Courtoy, C.

AU - Gillet, E.

AU - Amrane, Sophie

AU - Huynen, P.

AU - Van Esbroeck, M.

AU - Prudent, E.

AU - Lepidi, H.

AU - Million, Matthieu

AU - Moutschen, M.

AU - Raoult, Didier

N1 - FTX; DOAJ

PY - 2018

Y1 - 2018

N2 - A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen on F-18-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Given the aneurysm of the abdominal aorta, the patient underwent replacement of the abdominal aorta with an allograft. Histology showed intense chronic arteritis attributed to atherosclerosis with dissection. However, Coxiella burnetii infection was confirmed by serology and then by culture and molecular biology on the surgical specimen. A combination of hydroxychloroquine and doxycycline was added to tapered prednisolone and the outcome was favourable. (c) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.

AB - A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen on F-18-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Given the aneurysm of the abdominal aorta, the patient underwent replacement of the abdominal aorta with an allograft. Histology showed intense chronic arteritis attributed to atherosclerosis with dissection. However, Coxiella burnetii infection was confirmed by serology and then by culture and molecular biology on the surgical specimen. A combination of hydroxychloroquine and doxycycline was added to tapered prednisolone and the outcome was favourable. (c) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.

KW - Coxiella burnetii

KW - Giant cell arteritis

KW - Aortitis

KW - Q fever

KW - Vascular infection

KW - ACUTE Q-FEVER

KW - INFECTION

KW - VASCULOPATHY

KW - DIAGNOSIS

KW - PATIENT

U2 - 10.1016/j.ijid.2018.01.028

DO - 10.1016/j.ijid.2018.01.028

M3 - A1: Web of Science-article

SN - 1201-9712

VL - 69

SP - 50

EP - 54

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis

Abstract

Keywords

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