TY - JOUR
T1 - A comparison of HIV-1 and HIV-2 infections in hospitalized patients in Abidjan, Côte d'Ivoire
AU - De Cock, KM
AU - Koudou, O
AU - Colebunders, RL
AU - Adjorlolo, G
AU - Lafontaine, MF
AU - Porter, A
AU - Gnaore, E
AU - Diaby, L
AU - Moreau, J
AU - Heyward, WL
N1 - FTX print abonnement
PY - 1990
Y1 - 1990
N2 - In late 1988, a cross-sectional study of 1715 adult medical patients hospitalized in Abidjan, Côte d'lvoire, west Africa, showed an overall prevalence of HIV infection of 46% in men and 28% in women. On the basis of specific testing by whole virus enzyme-linked immunosorbent assay (ELISA), Western blot and synthetic peptide ELISA, HIV-1 infection was found in 25%, HIV-2 infection in 4%, and reactivity to both viruses in 11% of male and female patients combined. People infected with HIV-2, as well as those who were reactive to both HIV-1 and HIV-2, had a frequency of AIDS-associated symptoms and signs similar to that in HIV-1-infected patients, and significantly greater than that in seronegative patients. The significance of dual reactivity, and the natural history and disease spectrum of HIV-2 infection, require further study. Synthetic peptide ELISA is valuable for specific serodiagnosis of HIV-1 and HIV-2 infections. Advanced HIV-2 infection in hospitalized patients in Abidjan is associated with the same symptoms and signs as HIV-1 infection.
AB - In late 1988, a cross-sectional study of 1715 adult medical patients hospitalized in Abidjan, Côte d'lvoire, west Africa, showed an overall prevalence of HIV infection of 46% in men and 28% in women. On the basis of specific testing by whole virus enzyme-linked immunosorbent assay (ELISA), Western blot and synthetic peptide ELISA, HIV-1 infection was found in 25%, HIV-2 infection in 4%, and reactivity to both viruses in 11% of male and female patients combined. People infected with HIV-2, as well as those who were reactive to both HIV-1 and HIV-2, had a frequency of AIDS-associated symptoms and signs similar to that in HIV-1-infected patients, and significantly greater than that in seronegative patients. The significance of dual reactivity, and the natural history and disease spectrum of HIV-2 infection, require further study. Synthetic peptide ELISA is valuable for specific serodiagnosis of HIV-1 and HIV-2 infections. Advanced HIV-2 infection in hospitalized patients in Abidjan is associated with the same symptoms and signs as HIV-1 infection.
KW - B780-tropical-medicine
KW - HIV-2
KW - Viral diseases
KW - AIDS
KW - C“te d'Ivoire
KW - Africa-West
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:A1990DL18100011
U2 - 10.1097/00002030-199005000-00010
DO - 10.1097/00002030-199005000-00010
M3 - A1: Web of Science-article
SN - 0269-9370
VL - 4
SP - 443
EP - 448
JO - AIDS
JF - AIDS
ER -