A longitudinal study of the incidence of leprosy in a hyperendemic area in Zaire, with special reference to PGL-antibody results

G Groenen, SR Pattyn, P Ghys, T Kayembe, L Kuykens, MJ Colston, Group Yalisombo Study

Research output: Contribution to journalA1: Web of Science-article

Abstract

Between 1984 and 1988, yearly surveys for leprosy were done among the 1500 people living in a previous leprosy segregation village in Zaire. In 1984 lepromin tests and phenolic glycolipid (PGL) antibody tests were done in a significant part of the population. The prevalence of the disease at that time was 16.1%, the proportion of multibacillary cases was 11.3% overall and 22% among active cases. Prior to 1984, 23% of paucibacillary cases and 56% of multibacillary cases had presented themselves spontaneously to the Leprosy Service. The exposure to the infection is uniform, but there is a suggestion of family clustering of cases. In spite of a rapidly bactericidal treatment of all known cases in 1984 and thereafter, the annual incidence of 0.34% did not decrease during the 4 years of the study. The PGL antibody test did not contribute to the diagnosis, classification or prognosis of the disease
Original languageEnglish
JournalInternational Journal of Leprosy and Other Mycobacterial Diseases
Volume58
Pages (from-to)641-650
ISSN0148-916X
Publication statusPublished - 1990

Keywords

  • B780-tropical-medicine
  • Leprosy
  • Bacterial diseases
  • Incidence
  • Surveys
  • Antibodies
  • Congo-Kinshasa
  • Kisangani
  • Yalisombo
  • Africa-Central

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