A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense

P Büscher, E Depla, E Magnus, N Van Meirvenne

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Abstract

Аn antibody detection ELISA for diagnosis of Т.Ь. gambiense infection in man is presented. Тhe antigens consist of semi-purified variable surface glycoprotein of two different antigen types (VATs) of Т.Ь. gambiense. Both antigens were tested separately and as а mixture. А first evaluation of this ELISA оп 351 human Т.Ь. gambiense infection sera and 635 поп trypanosomiasis sera revealed high sensitivity and specificity. Тhe necessity of using а combination of VATs is demonstrated Ьу the rеlаtiопslliр between the geographical origin of the serum samples and the sensitivity of thee single antigen tests.
Original languageEnglish
Title of host publicationInternational Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993
EditorsKR Sones
Place of PublicationNairobi
PublisherOrganization of African Unity, Scientific and Technical Research Council (OAU/STRC)
Publication date1995
Pages46-52
Publication statusPublished - 1995

Keywords

  • B780-tropical-medicine
  • Protozoology
  • Trypanosoma brucei gambiense
  • Serology
  • ELISA

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