A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense

P Büscher; E Depla; E Magnus; N Van Meirvenne

A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense

P Büscher, E Depla, E Magnus, N Van Meirvenne

Institute of Tropical Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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Abstract

Аn antibody detection ELISA for diagnosis of Т.Ь. gambiense infection in man is presented. Тhe antigens consist of semi-purified variable surface glycoprotein of two different antigen types (VATs) of Т.Ь. gambiense. Both antigens were tested separately and as а mixture. А first evaluation of this ELISA оп 351 human Т.Ь. gambiense infection sera and 635 поп trypanosomiasis sera revealed high sensitivity and specificity. Тhe necessity of using а combination of VATs is demonstrated Ьу the rеlаtiопslliр between the geographical origin of the serum samples and the sensitivity of thee single antigen tests.

Original language	English
Title of host publication	International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993
Editors	KR Sones
Place of Publication	Nairobi
Publisher	Organization of African Unity, Scientific and Technical Research Council (OAU/STRC)
Publication date	1995
Pages	46-52
Publication status	Published - 1995

Keywords

B780-tropical-medicine
Protozoology
Trypanosoma brucei gambiense
Serology
ELISA

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Büscher, P., Depla, E., Magnus, E., & Van Meirvenne, N. (1995). A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense. In KR. Sones (Ed.), International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993 (pp. 46-52). Organization of African Unity, Scientific and Technical Research Council (OAU/STRC).

Büscher, P ; Depla, E ; Magnus, E et al. / A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense. International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993. editor / KR Sones. Nairobi : Organization of African Unity, Scientific and Technical Research Council (OAU/STRC), 1995. pp. 46-52

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abstract = "Аn antibody detection ELISA for diagnosis of Т.Ь. gambiense infection in man is presented. Тhe antigens consist of semi-purified variable surface glycoprotein of two different antigen types (VATs) of Т.Ь. gambiense. Both antigens were tested separately and as а mixture. А first evaluation of this ELISA оп 351 human Т.Ь. gambiense infection sera and 635 поп trypanosomiasis sera revealed high sensitivity and specificity. Тhe necessity of using а combination of VATs is demonstrated Ьу the rеlаtiопslliр between the geographical origin of the serum samples and the sensitivity of thee single antigen tests.",

keywords = "B780-tropical-medicine, Protozoology, Trypanosoma brucei gambiense, Serology, ELISA",

author = "P B{\"u}scher and E Depla and E Magnus and {Van Meirvenne}, N",

year = "1995",

language = "English",

pages = "46--52",

editor = "KR Sones",

booktitle = "International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993",

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Büscher, P, Depla, E, Magnus, E & Van Meirvenne, N 1995, A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense. in KR Sones (ed.), International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993. Organization of African Unity, Scientific and Technical Research Council (OAU/STRC), Nairobi, pp. 46-52.

A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense. / Büscher, P; Depla, E; Magnus, E et al.
International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993. ed. / KR Sones. Nairobi: Organization of African Unity, Scientific and Technical Research Council (OAU/STRC), 1995. p. 46-52.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Depla, E

AU - Magnus, E

AU - Van Meirvenne, N

PY - 1995

Y1 - 1995

N2 - Аn antibody detection ELISA for diagnosis of Т.Ь. gambiense infection in man is presented. Тhe antigens consist of semi-purified variable surface glycoprotein of two different antigen types (VATs) of Т.Ь. gambiense. Both antigens were tested separately and as а mixture. А first evaluation of this ELISA оп 351 human Т.Ь. gambiense infection sera and 635 поп trypanosomiasis sera revealed high sensitivity and specificity. Тhe necessity of using а combination of VATs is demonstrated Ьу the rеlаtiопslliр between the geographical origin of the serum samples and the sensitivity of thee single antigen tests.

AB - Аn antibody detection ELISA for diagnosis of Т.Ь. gambiense infection in man is presented. Тhe antigens consist of semi-purified variable surface glycoprotein of two different antigen types (VATs) of Т.Ь. gambiense. Both antigens were tested separately and as а mixture. А first evaluation of this ELISA оп 351 human Т.Ь. gambiense infection sera and 635 поп trypanosomiasis sera revealed high sensitivity and specificity. Тhe necessity of using а combination of VATs is demonstrated Ьу the rеlаtiопslliр between the geographical origin of the serum samples and the sensitivity of thee single antigen tests.

KW - B780-tropical-medicine

KW - Protozoology

KW - Trypanosoma brucei gambiense

KW - Serology

KW - ELISA

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EP - 52

BT - International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993

A2 - Sones, KR

PB - Organization of African Unity, Scientific and Technical Research Council (OAU/STRC)

CY - Nairobi

ER -

Büscher P, Depla E, Magnus E, Van Meirvenne N. A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense. In Sones KR, editor, International Scientific Council for Trypanosomiasis Research and Control (ISCTRC); twenty second meeting, Kampala, Uganda, 1993. Nairobi: Organization of African Unity, Scientific and Technical Research Council (OAU/STRC). 1995. p. 46-52

A serodiagnostic ELISA using variable antigens of Trypanosoma brucei gambiense

Abstract

Keywords

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