A simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria

T van Gool, ME van Wolfswinkel, R Koelewijn, PPAM van Thiel, J Jacobs, JJ van Hellemond, PJJ Van Genderen

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    BACKGROUND: Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. METHODS: In this study the Binax NOW(R) Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and aldolase as diagnostic markers, was used for semi-quantitative assessment of parasitaemia of P. faciparum. RESULTS: In 257 patients with imported P. falciparum malaria, reactivity of aldolase increased with higher parasitaemia. In all patients with a parasitaemia above 50,000 asexual parasites/ ul ( > 1%) co-reactivity of HRP-2 and aldolase was observed. Absence of aldolase reactivity in the presence of HRP-2 was a reliable predictive marker to exclude high (> 1%) parasitaemia in P. falciparum malaria. CONCLUSIONS: Assessment of HRP-2 and aldolase co-reactivity can be of help in clinical decision making in the acute care setting of returning travellers suspected of having malaria.
    Original languageEnglish
    JournalMalaria Journal
    Pages (from-to)300
    Number of pages5
    Publication statusPublished - 2011


    • B780-tropical-medicine
    • Protozoal diseases
    • Malaria
    • Plasmodium falciparum
    • Vectors
    • Mosquitoes
    • Anopheles
    • Imported
    • Travelers
    • Parasitemia
    • Rapid diagnostic tests
    • HRP-2
    • Efficiency
    • Netherlands
    • Belgium
    • Europe-West


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