Acute HIV illness following blood transfusion in three African children

R Colebunders; AE Greenberg; H Francis; N Kabote; I Lebughe; P Nguyen Dinh; TC Quinn; G van der Groen; JW Curran; P Piot

Acute HIV illness following blood transfusion in three African children

R Colebunders, AE Greenberg, H Francis, N Kabote, I Lebughe, P Nguyen Dinh, TC Quinn, G van der Groen, JW Curran, P Piot

Institute of Tropical Medicine

Research output: Contribution to journal › A2: International peer reviewed article (not A1-type) › peer-review

Abstract

Three children are described in whom pre-transfusion samples were HIV-seronegative and post-transfusional samples, obtained within 1 week after transfusion, were HIV-seropositive. Two of them developed a transient fever within 1 week of receiving the blood transfusion, and a transient generalized skin eruption which lasted for about 2 weeks. All three developed persistent generalized lymphadenopathy. One child developed a lumbar herpes zoster 7 months after transfusion. IgM Western blots demonstrated the presence of antibodies to protein bands p17, p24 and p55 in all three children. These three case reports suggest that children who receive a seropositive blood transfusion are at high risk for developing acute manifestations of HIV infection

Original language	English
Journal	AIDS
Volume	2
Pages (from-to)	125-127
ISSN	0269-9370
Publication status	Published - 1988

Keywords

B780-tropical-medicine
Viral diseases
Blood transfusion
HIV
Seropositivity
Etiology
Antibodies
Children
Immunoglobulin M
Cell count
T cells
Congo-Kinshasa
Africa-Central

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title = "Acute HIV illness following blood transfusion in three African children",

abstract = "Three children are described in whom pre-transfusion samples were HIV-seronegative and post-transfusional samples, obtained within 1 week after transfusion, were HIV-seropositive. Two of them developed a transient fever within 1 week of receiving the blood transfusion, and a transient generalized skin eruption which lasted for about 2 weeks. All three developed persistent generalized lymphadenopathy. One child developed a lumbar herpes zoster 7 months after transfusion. IgM Western blots demonstrated the presence of antibodies to protein bands p17, p24 and p55 in all three children. These three case reports suggest that children who receive a seropositive blood transfusion are at high risk for developing acute manifestations of HIV infection",

keywords = "B780-tropical-medicine, Viral diseases, Blood transfusion, HIV, Seropositivity, Etiology, Antibodies, Children, Immunoglobulin M, Cell count, T cells, Congo-Kinshasa, Africa-Central",

author = "R Colebunders and AE Greenberg and H Francis and N Kabote and I Lebughe and {Nguyen Dinh}, P and TC Quinn and {van der Groen}, G and JW Curran and P Piot",

year = "1988",

language = "English",

volume = "2",

pages = "125--127",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins",

}

TY - JOUR

T1 - Acute HIV illness following blood transfusion in three African children

AU - Colebunders, R

AU - Greenberg, AE

AU - Francis, H

AU - Kabote, N

AU - Lebughe, I

AU - Nguyen Dinh, P

AU - Quinn, TC

AU - van der Groen, G

AU - Curran, JW

AU - Piot, P

PY - 1988

Y1 - 1988

N2 - Three children are described in whom pre-transfusion samples were HIV-seronegative and post-transfusional samples, obtained within 1 week after transfusion, were HIV-seropositive. Two of them developed a transient fever within 1 week of receiving the blood transfusion, and a transient generalized skin eruption which lasted for about 2 weeks. All three developed persistent generalized lymphadenopathy. One child developed a lumbar herpes zoster 7 months after transfusion. IgM Western blots demonstrated the presence of antibodies to protein bands p17, p24 and p55 in all three children. These three case reports suggest that children who receive a seropositive blood transfusion are at high risk for developing acute manifestations of HIV infection

AB - Three children are described in whom pre-transfusion samples were HIV-seronegative and post-transfusional samples, obtained within 1 week after transfusion, were HIV-seropositive. Two of them developed a transient fever within 1 week of receiving the blood transfusion, and a transient generalized skin eruption which lasted for about 2 weeks. All three developed persistent generalized lymphadenopathy. One child developed a lumbar herpes zoster 7 months after transfusion. IgM Western blots demonstrated the presence of antibodies to protein bands p17, p24 and p55 in all three children. These three case reports suggest that children who receive a seropositive blood transfusion are at high risk for developing acute manifestations of HIV infection

KW - B780-tropical-medicine

KW - Viral diseases

KW - Blood transfusion

KW - HIV

KW - Seropositivity

KW - Etiology

KW - Antibodies

KW - Children

KW - Immunoglobulin M

KW - Cell count

KW - T cells

KW - Congo-Kinshasa

KW - Africa-Central

M3 - A2: International peer reviewed article (not A1-type)

SN - 0269-9370

VL - 2

SP - 125

EP - 127

JO - AIDS

JF - AIDS

ER -

Acute HIV illness following blood transfusion in three African children

Abstract

Keywords

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