ADAR1 edits the SenZ and SenZ-ability of RNA

Thomas Zillinger, Eva Bartok

    Research output: Contribution to journalEditorialpeer-review

    Abstract

    Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Za-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardi-Goutie` res syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.

    Original languageEnglish
    JournalImmunity
    Volume54
    Issue number9
    Pages (from-to)1909-1911
    Number of pages3
    DOIs
    Publication statusPublished - 2021

    Keywords

    • MUTATIONS
    • DOMAIN
    • DSRNA

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