ADAR1 edits the SenZ and SenZ-ability of RNA

Thomas Zillinger, Eva Bartok

Research output: Contribution to journalEditorial

Abstract

Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Za-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardi-Goutie` res syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.

Original languageEnglish
JournalImmunity
Volume54
Issue number9
Pages (from-to)1909-1911
Number of pages3
DOIs
Publication statusPublished - 2021

Keywords

  • MUTATIONS
  • DOMAIN
  • DSRNA

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