ADAR1 edits the SenZ and SenZ-ability of RNA

Thomas Zillinger; Eva Bartok

doi:10.1016/j.immuni.2021.08.021

ADAR1 edits the SenZ and SenZ-ability of RNA

Thomas Zillinger
, Eva Bartok

Research output: Contribution to journal › Editorial

Abstract

Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Za-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardi-Goutie` res syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.

Original language	English
Journal	Immunity
Volume	54
Issue number	9
Pages (from-to)	1909-1911
Number of pages	3
DOIs	https://doi.org/10.1016/j.immuni.2021.08.021
Publication status	Published - 2021

Keywords

MUTATIONS
DOMAIN
DSRNA

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title = "ADAR1 edits the SenZ and SenZ-ability of RNA",

abstract = "Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Za-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardi-Goutie` res syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.",

keywords = "MUTATIONS, DOMAIN, DSRNA",

author = "Thomas Zillinger and Eva Bartok",

note = "Bronze OA via publisher (open archive)",

year = "2021",

doi = "10.1016/j.immuni.2021.08.021",

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pages = "1909--1911",

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T1 - ADAR1 edits the SenZ and SenZ-ability of RNA

AU - Zillinger, Thomas

AU - Bartok, Eva

N1 - Bronze OA via publisher (open archive)

PY - 2021

Y1 - 2021

N2 - Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Za-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardi-Goutie` res syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.

AB - Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Za-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardi-Goutie` res syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.

KW - MUTATIONS

KW - DOMAIN

KW - DSRNA

U2 - 10.1016/j.immuni.2021.08.021

DO - 10.1016/j.immuni.2021.08.021

M3 - Editorial

VL - 54

SP - 1909

EP - 1911

JO - Immunity

JF - Immunity

IS - 9

ER -

ADAR1 edits the SenZ and SenZ-ability of RNA

Abstract

Keywords

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