TY - JOUR
T1 - Additional screening and treatment of malaria during pregnancy provides further protection against malaria and nonmalarial fevers during the first year of life
AU - Natama, Hamtandi Magloire
AU - Rovira-Vallbona, Eduard
AU - Sorgho, Hermann
AU - Somé, M Athanase
AU - Traoré-Coulibaly, Maminata
AU - Scott, Susana
AU - Zango, Serge Henri
AU - Sawadogo, Ousséni
AU - Zongo, Sibiri Claude
AU - Valéa, Innocent
AU - Mens, Petra F
AU - Schallig, Henk D F H
AU - Kestens, Luc
AU - Tinto, Halidou
AU - Rosanas-Urgell, Anna
N1 - PPU
PY - 2018
Y1 - 2018
N2 - Background: Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants.Methods: In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs.Results: Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval, .55-0.99]; P = .047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed.Conclusions: Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants.
AB - Background: Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants.Methods: In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs.Results: Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval, .55-0.99]; P = .047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed.Conclusions: Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants.
KW - Journal Article
U2 - 10.1093/infdis/jiy140
DO - 10.1093/infdis/jiy140
M3 - A1: Web of Science-article
C2 - 29659897
SN - 0022-1899
VL - 217
SP - 1967
EP - 1976
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -