Adherence to 7-day primaquine treatment for the radical cure of P. vivax in the Peruvian Amazon

K Peeters Grietens, V Soto, A Erhart, JM Ribera, E Toomer, A Tenorio, T Grande Montalvo, H Rodriguez, AL Cuentas, U D'Alessandro, D Gamboa

    Research output: Contribution to journalA1: Web of Science-articlepeer-review


    Despite being free of charge, treatment adherence to 7-day primaquine for the radical cure of Plasmodium vivax was estimated at 62.2% among patients along the Iquitos-Nauta road in the Peruvian Amazon. The principal reason for non-adherence was the perceived adverse effects related to local humoral illness conceptions that hold that malaria produces a hot state of body, which is further aggravated by the characteristically hot medical treatment. Notably, patients were willing to adhere to the first 3 days of treatment during which symptoms are most apparent and include the characteristic chills. Nevertheless, as symptoms abate, the perceived aggravating characteristics of the medication outweigh the perceived advantages of treatment adherence. Improving community awareness about the role of primaquine to prevent further malaria transmission and fostering a realistic system of direct observed treatment intake, organized at community level, can be expected to improve adherence to the radical cure of P. vivax in this area
    Original languageEnglish
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Issue number6
    Pages (from-to)1017-1023
    Number of pages7
    Publication statusPublished - 2010


    • B780-tropical-medicine
    • Protozoal diseases
    • Malaria
    • Plasmodium vivax
    • Vectors
    • Mosquitoes
    • Treatment
    • Free care
    • Primaquine
    • Compliance
    • Health care seeking behavior
    • Adverse effects
    • Fever
    • Symptoms
    • Patient's perspective
    • Awareness
    • Amazona
    • Peru
    • America-Latin


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