Affinity is an important determinant of the anti-Trypanosome activity of nanobodies

G. Caljon; B. Stijlemans; D. Saerens; J. Van Den Abbeele; S. Muyldermans; S. Magez; P. De Baetselier

doi:10.1371/journal.pntd.

Affinity is an important determinant of the anti-Trypanosome activity of nanobodies

G. Caljon
, B. Stijlemans
, D. Saerens
, J. Van Den Abbeele
, S. Muyldermans
, S. Magez
, P. De Baetselier

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

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Original language	English
Journal	PLoS Neglected Tropical Diseases
Volume	6
Issue number	11
Pages (from-to)	e1902
ISSN	1935-2727
DOIs	https://doi.org/10.1371/journal.pntd.
Publication status	Published - 2012

Keywords

Protozoal diseases
Trypanosomiasis-African
Sleeping sickness
Trypanosoma brucei
Vectors
Tsetse flies
Glossina morsitans
Treatment
Drug activity
Nanobodies
Variable surface glycoproteins
VSG
Epitopes
Toxicity
Affinity
Laboratory diagnosis

Access to Document

10.1371/journal.pntd.

2012pntde1902Final published version, 529 KB

Cite this

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title = "Affinity is an important determinant of the anti-Trypanosome activity of nanobodies",

keywords = "Protozoal diseases, Trypanosomiasis-African, Sleeping sickness, Trypanosoma brucei, Vectors, Tsetse flies, Glossina morsitans, Treatment, Drug activity, Nanobodies, Variable surface glycoproteins, VSG, Epitopes, Toxicity, Affinity, Laboratory diagnosis",

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AU - Caljon, G.

AU - Stijlemans, B.

AU - Saerens, D.

AU - Van Den Abbeele, J.

AU - Muyldermans, S.

AU - Magez, S.

AU - De Baetselier, P.

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KW - Sleeping sickness

KW - Trypanosoma brucei

KW - Vectors

KW - Tsetse flies

KW - Glossina morsitans

KW - Treatment

KW - Drug activity

KW - Nanobodies

KW - Variable surface glycoproteins

KW - VSG

KW - Epitopes

KW - Toxicity

KW - Affinity

KW - Laboratory diagnosis

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