TY - JOUR
T1 - African trypanosome control in the insect vector and mammalian host
AU - Beschin, Alain
AU - Van Den Abbeele, Jakke
AU - De Baetselier, Patrick
AU - Pays, Etienne
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014
Y1 - 2014
N2 - The life cycle of African trypanosomes involves adaptations to the defense mechanisms of two completely different hosts, the insect vector Glossina and the mammalian host. This interplay ultimately determines host resistance and/or tolerance to parasite infection. In the tsetse fly, the immune deficiency (IMD)-regulated pathway, the scavenger receptor peptidoglycan-recognition protein LB (PGRP-LB), and the reactive oxygen species (ROS)-mediated response modulate the insect's capacity to transmit the parasite. In experimental mice, control of parasite burden and tissue pathogenicity relies on timely regulated interactions between myeloid cells exhibiting distinct activation states (M1 versus M2 type). Tsetse fly saliva and various trypanosome components including adenylate cyclases, DNA, a kinesin heavy chain, and variant surface glycoprotein (VSG) interfere with resistance and tolerance to infection.
AB - The life cycle of African trypanosomes involves adaptations to the defense mechanisms of two completely different hosts, the insect vector Glossina and the mammalian host. This interplay ultimately determines host resistance and/or tolerance to parasite infection. In the tsetse fly, the immune deficiency (IMD)-regulated pathway, the scavenger receptor peptidoglycan-recognition protein LB (PGRP-LB), and the reactive oxygen species (ROS)-mediated response modulate the insect's capacity to transmit the parasite. In experimental mice, control of parasite burden and tissue pathogenicity relies on timely regulated interactions between myeloid cells exhibiting distinct activation states (M1 versus M2 type). Tsetse fly saliva and various trypanosome components including adenylate cyclases, DNA, a kinesin heavy chain, and variant surface glycoprotein (VSG) interfere with resistance and tolerance to infection.
U2 - 10.1016/j.pt.2014.08.006
DO - 10.1016/j.pt.2014.08.006
M3 - A1: Web of Science-article
C2 - 25246021
VL - 30
SP - 538
EP - 547
JO - Trends In Parasitology
JF - Trends In Parasitology
SN - 1471-4922
IS - 11
ER -