African trypanosome control in the insect vector and mammalian host

Alain Beschin, Jakke Van Den Abbeele, Patrick De Baetselier, Etienne Pays

Research output: Contribution to journalA1: Web of Science-article

1 Downloads (Pure)

Abstract

The life cycle of African trypanosomes involves adaptations to the defense mechanisms of two completely different hosts, the insect vector Glossina and the mammalian host. This interplay ultimately determines host resistance and/or tolerance to parasite infection. In the tsetse fly, the immune deficiency (IMD)-regulated pathway, the scavenger receptor peptidoglycan-recognition protein LB (PGRP-LB), and the reactive oxygen species (ROS)-mediated response modulate the insect's capacity to transmit the parasite. In experimental mice, control of parasite burden and tissue pathogenicity relies on timely regulated interactions between myeloid cells exhibiting distinct activation states (M1 versus M2 type). Tsetse fly saliva and various trypanosome components including adenylate cyclases, DNA, a kinesin heavy chain, and variant surface glycoprotein (VSG) interfere with resistance and tolerance to infection.

Original languageEnglish
JournalTrends In Parasitology
Volume30
Issue number11
Pages (from-to)538-547
ISSN1471-4922
DOIs
Publication statusPublished - 2014

Fingerprint Dive into the research topics of 'African trypanosome control in the insect vector and mammalian host'. Together they form a unique fingerprint.

Cite this