Alice in microbes' land: adaptations and counter-adaptations of vector-borne parasitic protozoa and their hosts

Guy Caljon, Géraldine De Muylder, Lies Durnez, Wim Jennes, Manu Vanaerschot, Jean-Claude Dujardin

Research output: Contribution to journalA1: Web of Science-article

Abstract

In the present review, we aim to provide a general introduction to different facets of the arms race between pathogens and their hosts/environment, emphasizing its evolutionary aspects. We focus on vector-borne parasitic protozoa, which have to adapt to both invertebrate and vertebrate hosts. Using Leishmania, Trypanosoma and Plasmodium as main models, we review successively (i) the adaptations and counter-adaptations of parasites and their invertebrate host, (ii) the adaptations and counter-adaptations of parasites and their vertebrate host and (iii) the impact of human interventions (chemotherapy, vaccination, vector control and environmental changes) on these adaptations. We conclude by discussing the practical impact this knowledge can have on translational research and public health.

Original languageEnglish
JournalFEMS Microbiology Reviews
Volume40
Issue number5
Pages (from-to)664-685
Number of pages22
ISSN0168-6445
DOIs
Publication statusPublished - 2016

Fingerprint Dive into the research topics of 'Alice in microbes' land: adaptations and counter-adaptations of vector-borne parasitic protozoa and their hosts'. Together they form a unique fingerprint.

Cite this