AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab

Jean-Baptiste Ronat; Alessandra Natale; Thomas Kesteman; Antoine Andremont; Wael Elamin; Liselotte Hardy; Rupa Kanapathipillai; Justine Michel; Celine Langendorf; Olivier Vandenberg; Thierry Naas; Felix Kouassi

doi:10.1016/j.cmi.2021.04.015

AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab

Jean-Baptiste Ronat, Alessandra Natale, Thomas Kesteman, Antoine Andremont, Wael Elamin, Liselotte Hardy, Rupa Kanapathipillai, Justine Michel, Celine Langendorf, Olivier Vandenberg, Thierry Naas, Felix Kouassi

Tropical Bacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

Background: In lowand middle-income countries (LMICs), data related to antimicrobial resistance (AMR) are often inconsistently collected. Humanitarian, private and non-governmental medical organizations (NGOs), working with or in parallel to public medical systems, are sometimes present in these contexts. Yet, what is the role of NGOs in the fight against AMR, and how can they contribute to AMR data collection in contexts where reporting is scarce? How can context-adapted, high-quality clinical bacteriology be implemented in remote, challenging and underserved areas of the world?

Objectives: The aim was to provide an overview of AMR data collection challenges in LMICs and describe one initiative, the Mini-Lab project developed by Medecins Sans Frontieres (MSF), that attempts to partially address them.

Sources: We conducted a literature review using PubMed and Google scholar databases to identify peer reviewed research and grey literature from publicly available reports and websites.

Content: We address the necessity of and difficulties related to obtaining AMR data in LMICs, as well as the role that actors outside of public medical systems can play in the collection of this information. We then describe how the Mini-Lab can provide simplified bacteriological diagnosis and AMR surveillance in challenging settings.

Implications: NGOs are responsible for a large amount of healthcare provision in some very lowresourced contexts. As a result, they also have a role in AMR control, including bacteriological diagnosis and the collection of AMR-related data. Actors outside the public medical system can actively contribute to implementing and adapting clinical bacteriology in LMICs and can help improve AMR surveillance and data collection. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Original language	English
Journal	Clinical Microbiology and Infection
Volume	27
Issue number	10
Pages (from-to)	1414-1421
Number of pages	8
ISSN	1198-743X
DOIs	https://doi.org/10.1016/j.cmi.2021.04.015
Publication status	Published - 2021

Keywords

Antimicrobial resistance
Clinical bacteriology laboratory
Low- and middle-income countries
Mini-Lab
Medecins Sans Frontieres
Surveillance
IMPLEMENTATION

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Ronat, J.-B., Natale, A., Kesteman, T., Andremont, A., Elamin, W., Hardy, L., Kanapathipillai, R., Michel, J., Langendorf, C., Vandenberg, O., Naas, T., & Kouassi, F. (2021). AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab. Clinical Microbiology and Infection, 27(10), 1414-1421. https://doi.org/10.1016/j.cmi.2021.04.015

@article{965159380af7431f81681acc8c0d0a8f,

title = "AMR in low-resource settings: M{\'e}decins Sans Fronti{\`e}res bridges surveillance gaps by developing a turnkey solution, the Mini-Lab",

abstract = "Background: In lowand middle-income countries (LMICs), data related to antimicrobial resistance (AMR) are often inconsistently collected. Humanitarian, private and non-governmental medical organizations (NGOs), working with or in parallel to public medical systems, are sometimes present in these contexts. Yet, what is the role of NGOs in the fight against AMR, and how can they contribute to AMR data collection in contexts where reporting is scarce? How can context-adapted, high-quality clinical bacteriology be implemented in remote, challenging and underserved areas of the world?Objectives: The aim was to provide an overview of AMR data collection challenges in LMICs and describe one initiative, the Mini-Lab project developed by Medecins Sans Frontieres (MSF), that attempts to partially address them.Sources: We conducted a literature review using PubMed and Google scholar databases to identify peer reviewed research and grey literature from publicly available reports and websites.Content: We address the necessity of and difficulties related to obtaining AMR data in LMICs, as well as the role that actors outside of public medical systems can play in the collection of this information. We then describe how the Mini-Lab can provide simplified bacteriological diagnosis and AMR surveillance in challenging settings.Implications: NGOs are responsible for a large amount of healthcare provision in some very lowresourced contexts. As a result, they also have a role in AMR control, including bacteriological diagnosis and the collection of AMR-related data. Actors outside the public medical system can actively contribute to implementing and adapting clinical bacteriology in LMICs and can help improve AMR surveillance and data collection. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

keywords = "Antimicrobial resistance, Clinical bacteriology laboratory, Low- and middle-income countries, Mini-Lab, Medecins Sans Frontieres, Surveillance, IMPLEMENTATION",

author = "Jean-Baptiste Ronat and Alessandra Natale and Thomas Kesteman and Antoine Andremont and Wael Elamin and Liselotte Hardy and Rupa Kanapathipillai and Justine Michel and Celine Langendorf and Olivier Vandenberg and Thierry Naas and Felix Kouassi",

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year = "2021",

doi = "10.1016/j.cmi.2021.04.015",

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Ronat, J-B, Natale, A, Kesteman, T, Andremont, A, Elamin, W, Hardy, L, Kanapathipillai, R, Michel, J, Langendorf, C, Vandenberg, O, Naas, T & Kouassi, F 2021, 'AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab', Clinical Microbiology and Infection, vol. 27, no. 10, pp. 1414-1421. https://doi.org/10.1016/j.cmi.2021.04.015

TY - JOUR

T1 - AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab

AU - Ronat, Jean-Baptiste

AU - Natale, Alessandra

AU - Kesteman, Thomas

AU - Andremont, Antoine

AU - Elamin, Wael

AU - Hardy, Liselotte

AU - Kanapathipillai, Rupa

AU - Michel, Justine

AU - Langendorf, Celine

AU - Vandenberg, Olivier

AU - Naas, Thierry

AU - Kouassi, Felix

N1 - FTX; OGOA; (CC BY-NC-ND 4.0)

PY - 2021

Y1 - 2021

N2 - Background: In lowand middle-income countries (LMICs), data related to antimicrobial resistance (AMR) are often inconsistently collected. Humanitarian, private and non-governmental medical organizations (NGOs), working with or in parallel to public medical systems, are sometimes present in these contexts. Yet, what is the role of NGOs in the fight against AMR, and how can they contribute to AMR data collection in contexts where reporting is scarce? How can context-adapted, high-quality clinical bacteriology be implemented in remote, challenging and underserved areas of the world?Objectives: The aim was to provide an overview of AMR data collection challenges in LMICs and describe one initiative, the Mini-Lab project developed by Medecins Sans Frontieres (MSF), that attempts to partially address them.Sources: We conducted a literature review using PubMed and Google scholar databases to identify peer reviewed research and grey literature from publicly available reports and websites.Content: We address the necessity of and difficulties related to obtaining AMR data in LMICs, as well as the role that actors outside of public medical systems can play in the collection of this information. We then describe how the Mini-Lab can provide simplified bacteriological diagnosis and AMR surveillance in challenging settings.Implications: NGOs are responsible for a large amount of healthcare provision in some very lowresourced contexts. As a result, they also have a role in AMR control, including bacteriological diagnosis and the collection of AMR-related data. Actors outside the public medical system can actively contribute to implementing and adapting clinical bacteriology in LMICs and can help improve AMR surveillance and data collection. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

AB - Background: In lowand middle-income countries (LMICs), data related to antimicrobial resistance (AMR) are often inconsistently collected. Humanitarian, private and non-governmental medical organizations (NGOs), working with or in parallel to public medical systems, are sometimes present in these contexts. Yet, what is the role of NGOs in the fight against AMR, and how can they contribute to AMR data collection in contexts where reporting is scarce? How can context-adapted, high-quality clinical bacteriology be implemented in remote, challenging and underserved areas of the world?Objectives: The aim was to provide an overview of AMR data collection challenges in LMICs and describe one initiative, the Mini-Lab project developed by Medecins Sans Frontieres (MSF), that attempts to partially address them.Sources: We conducted a literature review using PubMed and Google scholar databases to identify peer reviewed research and grey literature from publicly available reports and websites.Content: We address the necessity of and difficulties related to obtaining AMR data in LMICs, as well as the role that actors outside of public medical systems can play in the collection of this information. We then describe how the Mini-Lab can provide simplified bacteriological diagnosis and AMR surveillance in challenging settings.Implications: NGOs are responsible for a large amount of healthcare provision in some very lowresourced contexts. As a result, they also have a role in AMR control, including bacteriological diagnosis and the collection of AMR-related data. Actors outside the public medical system can actively contribute to implementing and adapting clinical bacteriology in LMICs and can help improve AMR surveillance and data collection. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

KW - Antimicrobial resistance

KW - Clinical bacteriology laboratory

KW - Low- and middle-income countries

KW - Mini-Lab

KW - Medecins Sans Frontieres

KW - Surveillance

KW - IMPLEMENTATION

U2 - 10.1016/j.cmi.2021.04.015

DO - 10.1016/j.cmi.2021.04.015

M3 - A1: Web of Science-article

SN - 1198-743X

VL - 27

SP - 1414

EP - 1421

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 10

ER -

AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab

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Keywords

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