Abstract
The anti-Mycobacterium leprae activity of several fluoroquinolones (A-56619, A-56620, ofloxacin, fleroxacin, lomefloxacin, temafloxacin, tosufloxacin, and PD-117596) was studied in the mouse. In a dosage of 150 mg/kg administered daily, A-56619 is active and A-56620 is inactive against M. leprae. Ofloxacin administered daily for 2 weeks at 300 mg/kg is bactericidal. The minimal effective dose of PD-117596, lomefloxacin and temafloxacin is less than 37.5 mg/kg. When administered at 300 mg/kg at monthly intervals temafloxacin, PD-117596, and ofloxacin are bacteriostatic; while fleroxacin and lomefloxacin are bactericidal. Tosufloxacin is less active than the other quinolones included in the present study.
| Original language | English |
|---|---|
| Journal | International Journal of Leprosy and Other Mycobacterial Diseases |
| Volume | 59 |
| Issue number | 4 |
| Pages (from-to) | 613-617 |
| Number of pages | 5 |
| ISSN | 0148-916X |
| Publication status | Published - 1991 |
Keywords
- B780-tropical-medicine
- Bacteriology
- Mycobacterium leprae
- Treatment
- Quinolones
- Experimental
- Fluoroquinolones