Antibiotic therapy for acute Q fever in The Netherlands in 2007 and 2008 and its relation to hospitalization

F Dijkstra, J Riphagen-Dalhuisen, N Wijers, E Hak, M A B Van der Sande, G Morroy, P M Schneeberger, B Schimmer, D W Notermans, W Van der Hoek

Research output: Contribution to journalA1: Web of Science-articlepeer-review


Data about the effectiveness of different antibiotic regimens for the treatment of acute Q fever from clinical studies is scarce. We analysed the antibiotic treatment regimens of acute Q fever patients in 2007 and 2008 in The Netherlands and assessed whether hospitalization after a minimum of 2 days antibiotic therapy was related to the initial antibiotic therapy. Clinical data on antibiotic treatment and risk factors of acute Q fever patients were obtained from general practitioner medical records and self-reported by patients. For the 438 study patients, doxycycline was the most commonly prescribed initial antibiotic in both study years. After adjustments for confounding factors, doxycycline (200 mg/day), moxifloxacin, as well as other possibly effective antibiotics [including other new fluoroquinolones and doxycycline (100 mg/day)] showed significant lower risks for hospitalization compared to β-lactam antibiotics and azithromycin (reference group), with the lowest risk for doxycycline (200 mg/day) (odds ratio 0·04, 95% confidence interval 0·01-0·22). These data support current guidelines that recommend doxycycline as the first choice antibiotic for treating acute Q fever.

Original languageEnglish
JournalEpidemiology and Infection
Issue number9
Pages (from-to)1332-1341
Number of pages10
Publication statusPublished - 2011


  • Anti-Infective Agents/therapeutic use
  • Doxycycline/therapeutic use
  • Female
  • Hospitalization/statistics & numerical data
  • Humans
  • Male
  • Netherlands/epidemiology
  • Q Fever/drug therapy
  • Risk Factors
  • Severity of Illness Index
  • Treatment Outcome


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