Antimicrobial resistance and COVID-19: intersections and implications

Gwenan M. Knight; Rebecca E. Glover; C. Finn McQuaid; Ioana D. Olaru; Karin Gallandat; Quentin J. Leclerc; Naomi M. Fuller; Sam J. Willcocks; Rumina Hasan; Esther van Kleef; Clare I. R. Chandler

doi:10.7554/eLife.64139

Antimicrobial resistance and COVID-19: intersections and implications

Gwenan M. Knight, Rebecca E. Glover, C. Finn McQuaid, Ioana D. Olaru, Karin Gallandat, Quentin J. Leclerc, Naomi M. Fuller, Sam J. Willcocks, Rumina Hasan, Esther van Kleef, Clare I. R. Chandler

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Abstract

Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased international travel, and decreased elective hospital procedures may reduce AMR pathogen selection and spread in the short term. However, the opposite effects may be seen if antibiotics are more widely used as standard healthcare pathways break down. Over 6 months into the COVID-19 pandemic, the dynamics of AMR remain uncertain. We call for the AMR community to keep a global perspective while designing finely tuned surveillance and research to continue to improve our preparedness and response to these intersecting public health challenges.

Original language	English
Article number	64139
Journal	eLIFE
Volume	10
Number of pages	27
ISSN	2050-084X
DOIs	https://doi.org/10.7554/eLife.64139
Publication status	Published - 2021

Keywords

Anti-Bacterial Agents/supply & distribution
COVID-19/drug therapy
Communicable Disease Control/methods
Critical Pathways/organization & administration
Drug Resistance, Bacterial/physiology
Global Health/trends
Humans
SARS-CoV-2

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2021elife64139Final published version, 569 KBLicence: CC BY

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title = "Antimicrobial resistance and COVID-19: intersections and implications",

abstract = "Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased international travel, and decreased elective hospital procedures may reduce AMR pathogen selection and spread in the short term. However, the opposite effects may be seen if antibiotics are more widely used as standard healthcare pathways break down. Over 6 months into the COVID-19 pandemic, the dynamics of AMR remain uncertain. We call for the AMR community to keep a global perspective while designing finely tuned surveillance and research to continue to improve our preparedness and response to these intersecting public health challenges.",

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AU - Knight, Gwenan M.

AU - Glover, Rebecca E.

AU - McQuaid, C. Finn

AU - Olaru, Ioana D.

AU - Gallandat, Karin

AU - Leclerc, Quentin J.

AU - Fuller, Naomi M.

AU - Willcocks, Sam J.

AU - Hasan, Rumina

AU - van Kleef, Esther

AU - Chandler, Clare I. R.

N1 - FTX; DOAJ; (CC BY 4.0)

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N2 - Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased international travel, and decreased elective hospital procedures may reduce AMR pathogen selection and spread in the short term. However, the opposite effects may be seen if antibiotics are more widely used as standard healthcare pathways break down. Over 6 months into the COVID-19 pandemic, the dynamics of AMR remain uncertain. We call for the AMR community to keep a global perspective while designing finely tuned surveillance and research to continue to improve our preparedness and response to these intersecting public health challenges.

AB - Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased international travel, and decreased elective hospital procedures may reduce AMR pathogen selection and spread in the short term. However, the opposite effects may be seen if antibiotics are more widely used as standard healthcare pathways break down. Over 6 months into the COVID-19 pandemic, the dynamics of AMR remain uncertain. We call for the AMR community to keep a global perspective while designing finely tuned surveillance and research to continue to improve our preparedness and response to these intersecting public health challenges.

KW - Anti-Bacterial Agents/supply & distribution

KW - COVID-19/drug therapy

KW - Communicable Disease Control/methods

KW - Critical Pathways/organization & administration

KW - Drug Resistance, Bacterial/physiology

KW - Global Health/trends

KW - Humans

KW - SARS-CoV-2

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DO - 10.7554/eLife.64139

M3 - A1: Web of Science-article

C2 - 33588991

SN - 2050-084X

VL - 10

JO - eLIFE

JF - eLIFE

M1 - 64139

ER -

Antimicrobial resistance and COVID-19: intersections and implications

Abstract

Keywords

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