Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata

G François; CM Passreiter; HJ Woerdenbag; M Van Looveren

doi:10.1055/s-2006-957833

Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata

G François, CM Passreiter, HJ Woerdenbag, M Van Looveren

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.

Original language	English
Journal	Planta Medica
Volume	62
Issue number	2
Pages (from-to)	126-129
Number of pages	4
ISSN	0032-0943
DOIs	https://doi.org/10.1055/s-2006-957833
Publication status	Published - 1996

Keywords

B780-tropical-medicine
Protozoal diseases
Malaria
Neurolaena lobata
Medicinal plants

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10.1055/s-2006-957833

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title = "Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata",

abstract = "Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.",

keywords = "B780-tropical-medicine, Protozoal diseases, Malaria, Neurolaena lobata, Medicinal plants",

author = "G Fran{\c c}ois and CM Passreiter and HJ Woerdenbag and {Van Looveren}, M",

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doi = "10.1055/s-2006-957833",

language = "English",

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T1 - Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata

AU - François, G

AU - Passreiter, CM

AU - Woerdenbag, HJ

AU - Van Looveren, M

N1 - FTX: ITM does not have access to this article

PY - 1996

Y1 - 1996

N2 - Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.

AB - Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.

KW - B780-tropical-medicine

KW - Protozoal diseases

KW - Malaria

KW - Neurolaena lobata

KW - Medicinal plants

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:A1996UJ48100007

U2 - 10.1055/s-2006-957833

DO - 10.1055/s-2006-957833

M3 - A1: Web of Science-article

SN - 0032-0943

VL - 62

SP - 126

EP - 129

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata

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