Antiplasmodial activity of mono- and dimeric carbazoles

G Bringmann; A Ledermann; J Holenz; MT Kao; U Busse; HG Wu; G François

doi:10.1055/s-2006-957366

Antiplasmodial activity of mono- and dimeric carbazoles

G Bringmann, A Ledermann, J Holenz, MT Kao, U Busse, HG Wu, G François

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).

Original language	English
Journal	Planta Medica
Volume	64
Issue number	1
Pages (from-to)	54-57
ISSN	0032-0943
DOIs	https://doi.org/10.1055/s-2006-957366
Publication status	Published - 1998

Keywords

B780-tropical-medicine
Protozoal diseases
Malaria
Plasmodium falciparum
Vectors
Mosquitoes
Anopheles
Drug development
Murrayfoline
Antimalarials

Access to Document

10.1055/s-2006-957366

Cite this

@article{bafee5ddd05d487096367ebc5ada362e,

title = "Antiplasmodial activity of mono- and dimeric carbazoles",

abstract = "A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).",

keywords = "B780-tropical-medicine, Protozoal diseases, Malaria, Plasmodium falciparum, Vectors, Mosquitoes, Anopheles, Drug development, Murrayfoline, Antimalarials",

author = "G Bringmann and A Ledermann and J Holenz and MT Kao and U Busse and HG Wu and G Fran{\c c}ois",

year = "1998",

doi = "10.1055/s-2006-957366",

language = "English",

volume = "64",

pages = "54--57",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "1",

}

TY - JOUR

T1 - Antiplasmodial activity of mono- and dimeric carbazoles

AU - Bringmann, G

AU - Ledermann, A

AU - Holenz, J

AU - Kao, MT

AU - Busse, U

AU - Wu, HG

AU - François, G

PY - 1998

Y1 - 1998

N2 - A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).

AB - A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).

KW - B780-tropical-medicine

KW - Protozoal diseases

KW - Malaria

KW - Plasmodium falciparum

KW - Vectors

KW - Mosquitoes

KW - Anopheles

KW - Drug development

KW - Murrayfoline

KW - Antimalarials

U2 - 10.1055/s-2006-957366

DO - 10.1055/s-2006-957366

M3 - A1: Web of Science-article

C2 - 9491767

SN - 0032-0943

VL - 64

SP - 54

EP - 57

JO - Planta Medica

JF - Planta Medica

IS - 1

ER -

Antiplasmodial activity of mono- and dimeric carbazoles

Abstract

Keywords

Access to Document

Fingerprint

Cite this