Antiplasmodial activity of mono- and dimeric carbazoles

G Bringmann, A Ledermann, J Holenz, MT Kao, U Busse, HG Wu, G François

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).
    Original languageEnglish
    JournalPlanta Medica
    Volume64
    Issue number1
    Pages (from-to)54-57
    ISSN0032-0943
    DOIs
    Publication statusPublished - 1998

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Malaria
    • Plasmodium falciparum
    • Vectors
    • Mosquitoes
    • Anopheles
    • Drug development
    • Murrayfoline
    • Antimalarials

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