Abstract
A comprehensive review of the available methods for the analysis of isoflavonoids and lignans in biological matrices based on coulometric electrode array detection (CEAD) is presented. Different aspects such as sample extraction and purification procedures as well as instrumental settings and method validation are discussed. Comparisons with other available protocols using different detection techniques such as mass spectrometry or immunoassay are also reported to underline the versatility and reliability of the detector. Practical notes and tips for scientists working with CEAD are also provided. (c) 2006 Elsevier B.V. All rights reserved.
| Original language | English |
|---|---|
| Journal | Journal of Pharmaceutical and Biomedical Analysis |
| Volume | 41 |
| Issue number | 5 |
| Pages (from-to) | 1497-1507 |
| Number of pages | 11 |
| ISSN | 0731-7085 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
Keywords
- coularray
- coulometric
- isoflavonoids
- lignans
- phytoestrogens
- PERFORMANCE LIQUID-CHROMATOGRAPHY
- MASS-SPECTROMETRIC METHOD
- TIME-RESOLVED FLUOROIMMUNOASSAY
- PLANT LIGNANS
- HUMAN PLASMA
- HUMAN URINE
- INTESTINAL METABOLISM
- SERUM ENTEROLACTONE
- MAMMALIAN LIGNANS
- RED-CLOVER