Assessing the impact of a joint human-porcine intervention package for Taenia solium control: results of a pilot study from northern Lao PDR

Anna L Okello; Lian Thomas; Phouth Inthavong; Amanda Ash; Boualam Khamlome; Chattouphone Keokamphet; Kim Newberry; Charles G Gauci; Sarah Gabriël; Pierre Dorny; Rc Andrew Thompson; Marshall W Lightowlers; John Allen

doi:10.1016/j.actatropica.2016.03.012

Assessing the impact of a joint human-porcine intervention package for Taenia solium control: results of a pilot study from northern Lao PDR

Anna L Okello, Lian Thomas, Phouth Inthavong, Amanda Ash, Boualam Khamlome, Chattouphone Keokamphet, Kim Newberry, Charles G Gauci, Sarah Gabriël, Pierre Dorny, Rc Andrew Thompson, Marshall W Lightowlers, John Allen

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.

Original language	English
Journal	Acta Tropica
Volume	159
Pages (from-to)	185-191
Number of pages	7
ISSN	0001-706X
DOIs	https://doi.org/10.1016/j.actatropica.2016.03.012
Publication status	Published - 2016

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Journal Article

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Okello, A. L., Thomas, L., Inthavong, P., Ash, A., Khamlome, B., Keokamphet, C., Newberry, K., Gauci, C. G., Gabriël, S., Dorny, P., Thompson, R. A., Lightowlers, M. W., & Allen, J. (2016). Assessing the impact of a joint human-porcine intervention package for Taenia solium control: results of a pilot study from northern Lao PDR. Acta Tropica, 159, 185-191. https://doi.org/10.1016/j.actatropica.2016.03.012

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title = "Assessing the impact of a joint human-porcine intervention package for Taenia solium control: results of a pilot study from northern Lao PDR",

abstract = "Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.",

keywords = "Journal Article",

author = "Okello, {Anna L} and Lian Thomas and Phouth Inthavong and Amanda Ash and Boualam Khamlome and Chattouphone Keokamphet and Kim Newberry and Gauci, {Charles G} and Sarah Gabri{\"e}l and Pierre Dorny and Thompson, {Rc Andrew} and Lightowlers, {Marshall W} and John Allen",

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doi = "10.1016/j.actatropica.2016.03.012",

language = "English",

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Okello, AL, Thomas, L, Inthavong, P, Ash, A, Khamlome, B, Keokamphet, C, Newberry, K, Gauci, CG, Gabriël, S, Dorny, P, Thompson, RA, Lightowlers, MW & Allen, J 2016, 'Assessing the impact of a joint human-porcine intervention package for Taenia solium control: results of a pilot study from northern Lao PDR', Acta Tropica, vol. 159, pp. 185-191. https://doi.org/10.1016/j.actatropica.2016.03.012

TY - JOUR

T1 - Assessing the impact of a joint human-porcine intervention package for Taenia solium control

T2 - results of a pilot study from northern Lao PDR

AU - Okello, Anna L

AU - Thomas, Lian

AU - Inthavong, Phouth

AU - Ash, Amanda

AU - Khamlome, Boualam

AU - Keokamphet, Chattouphone

AU - Newberry, Kim

AU - Gauci, Charles G

AU - Gabriël, Sarah

AU - Dorny, Pierre

AU - Thompson, Rc Andrew

AU - Lightowlers, Marshall W

AU - Allen, John

PY - 2016

Y1 - 2016

N2 - Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.

AB - Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later. Community and individual human taeniasis prevalences were estimated via copro-antigen ELISA of volunteered human faecal samples prior to October 2013, and again in January 2015, in order to examine the short term impact of the intervention.

KW - Journal Article

U2 - 10.1016/j.actatropica.2016.03.012

DO - 10.1016/j.actatropica.2016.03.012

M3 - A1: Web of Science-article

C2 - 26992295

SN - 0001-706X

VL - 159

SP - 185

EP - 191

JO - Acta Tropica

JF - Acta Tropica

ER -

Assessing the impact of a joint human-porcine intervention package for Taenia solium control: results of a pilot study from northern Lao PDR

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