Assessment of cure by detection of circulating antigens in serum and urine, following schistosomiasis mass treatment in two villages of the Office du Niger, Mali

D De Clercq; M Sacko; J Vercruysse; V vanden Bussche; A Landouré; A Diarra; B Gryseels; A Deelder

doi:10.1016/S0001-706X(97)00111-3

Assessment of cure by detection of circulating antigens in serum and urine, following schistosomiasis mass treatment in two villages of the Office du Niger, Mali

D De Clercq, M Sacko, J Vercruysse, V vanden Bussche, A Landouré, A Diarra, B Gryseels, A Deelder

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Eight weeks after mass chemotherapy with 40 mg/kg praziquantel in two villages in Office du Niger (an irrigation area in Mali, endemic for both Schistosoma haematobium and Schistosoma mansoni) the circulating anodic (CAA) and cathodic (CCA) antigen detection assays were carried out on serum and urine samples. Both prior and post treatment highest prevalence was measured with the urine-CCA assay. Cure rates determined by antigen detection were almost half that of the egg counting methods. It was shown that the reduction in intensity should be preferentially assessed by the serum-CAA assay. Compared with egg detection, a single antigen detection assay gave a much better assessment of the impact of chemotherapy.

Original language	English
Journal	Acta Tropica
Volume	68
Issue number	3
Pages (from-to)	339-346
Number of pages	8
ISSN	0001-706X
DOIs	https://doi.org/10.1016/S0001-706X(97)00111-3
Publication status	Published - 1997

Keywords

B780-tropical-medicine
Helminthic diseases
Schistosomiasis
Mass drug therapy
Praziquantel
Treatment success
Antigen detection
Mali
Africa-West

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10.1016/S0001-706X(97)00111-3

http://lib.itg.be/pdf/itg/1997/1997atro0339.pdf

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@article{37d9a82395b340668e130022062f181c,

title = "Assessment of cure by detection of circulating antigens in serum and urine, following schistosomiasis mass treatment in two villages of the Office du Niger, Mali",

abstract = "Eight weeks after mass chemotherapy with 40 mg/kg praziquantel in two villages in Office du Niger (an irrigation area in Mali, endemic for both Schistosoma haematobium and Schistosoma mansoni) the circulating anodic (CAA) and cathodic (CCA) antigen detection assays were carried out on serum and urine samples. Both prior and post treatment highest prevalence was measured with the urine-CCA assay. Cure rates determined by antigen detection were almost half that of the egg counting methods. It was shown that the reduction in intensity should be preferentially assessed by the serum-CAA assay. Compared with egg detection, a single antigen detection assay gave a much better assessment of the impact of chemotherapy.",

keywords = "B780-tropical-medicine, Helminthic diseases, Schistosomiasis, Mass drug therapy, Praziquantel, Treatment success, Antigen detection, Mali, Africa-West",

author = "{De Clercq}, D and M Sacko and J Vercruysse and {vanden Bussche}, V and A Landour{\'e} and A Diarra and B Gryseels and A Deelder",

note = "FTX: Abonnement",

year = "1997",

doi = "10.1016/S0001-706X(97)00111-3",

language = "English",

volume = "68",

pages = "339--346",

journal = "Acta Tropica",

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TY - JOUR

T1 - Assessment of cure by detection of circulating antigens in serum and urine, following schistosomiasis mass treatment in two villages of the Office du Niger, Mali

AU - De Clercq, D

AU - Sacko, M

AU - Vercruysse, J

AU - vanden Bussche, V

AU - Landouré, A

AU - Diarra, A

AU - Gryseels, B

AU - Deelder, A

N1 - FTX: Abonnement

PY - 1997

Y1 - 1997

N2 - Eight weeks after mass chemotherapy with 40 mg/kg praziquantel in two villages in Office du Niger (an irrigation area in Mali, endemic for both Schistosoma haematobium and Schistosoma mansoni) the circulating anodic (CAA) and cathodic (CCA) antigen detection assays were carried out on serum and urine samples. Both prior and post treatment highest prevalence was measured with the urine-CCA assay. Cure rates determined by antigen detection were almost half that of the egg counting methods. It was shown that the reduction in intensity should be preferentially assessed by the serum-CAA assay. Compared with egg detection, a single antigen detection assay gave a much better assessment of the impact of chemotherapy.

AB - Eight weeks after mass chemotherapy with 40 mg/kg praziquantel in two villages in Office du Niger (an irrigation area in Mali, endemic for both Schistosoma haematobium and Schistosoma mansoni) the circulating anodic (CAA) and cathodic (CCA) antigen detection assays were carried out on serum and urine samples. Both prior and post treatment highest prevalence was measured with the urine-CCA assay. Cure rates determined by antigen detection were almost half that of the egg counting methods. It was shown that the reduction in intensity should be preferentially assessed by the serum-CAA assay. Compared with egg detection, a single antigen detection assay gave a much better assessment of the impact of chemotherapy.

KW - B780-tropical-medicine

KW - Helminthic diseases

KW - Schistosomiasis

KW - Mass drug therapy

KW - Praziquantel

KW - Treatment success

KW - Antigen detection

KW - Mali

KW - Africa-West

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000071684300009

U2 - 10.1016/S0001-706X(97)00111-3

DO - 10.1016/S0001-706X(97)00111-3

M3 - A1: Web of Science-article

SN - 0001-706X

VL - 68

SP - 339

EP - 346

JO - Acta Tropica

JF - Acta Tropica

IS - 3

ER -

Assessment of cure by detection of circulating antigens in serum and urine, following schistosomiasis mass treatment in two villages of the Office du Niger, Mali

Abstract

Keywords

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