Assessment of the long-term effect of vaccination on transmission of infectious bovine rhinotracheitis virus in cattle herds hyperimmunized with glycoprotein E-deleted marker vaccine

B. Ampe, L. Duchateau, N. Speybroeck, D. Berkvens, A. Dupont, P. Kerkhofs, E. Thiry, M. Dispas

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Objective-To assess long-term effects and risk factors for the efficacy of hyperimmunization protocols against infectious bovine rhinotracheitis (IBR) during a longitudinal field study of dairy and dairy-beef mixed farms. Animals-Approximately 7,700 cows from 72 farms. Procedures-Farms were assigned to 3 treatment groups (hyperimmunization groups [HIGs] 1 and 2, which were hyperimmunized with glycoprotein E [gE]-deleted marker vaccines, and a nonintervention group [NIG]). Cattle in HIG 1 were initially vaccinated with an attenuated vaccine, whereas cattle in HIG 2 were initially vaccinated with an inactivated-virus vaccine. Cattle in both HIGs received booster inoculations with inactivated-virus vaccines at 6-month intervals. The risk for gE seroconversion was compared among experimental groups via a shared frailty model with a piecewise constant baseline risk to correct for seasonal and secular effects. Results-Risk for gE seroconversion significantly decreased over time for the HIGs, compared with the NIG. Seasonal changes in the risk of gE seroconversion were detected, with a higher risk during winter periods, compared with grazing periods. No significant difference was detected between HIGs 1 and 2. The only significant risk factor was the number of buildings for cattle on a farm; the higher the number of buildings, the lower the risk for gE seroconversion. Prevalence of IBR decreased over time in both HIGs but remained constant or increased in the NIG. Conclusions and Clinical Relevance-Hyperimmunization via repeated administration of attenuated and inactivated-virus gE-deleted marker vaccines as well as inactivated-virus vaccines may provide a method for control of IBR.
    Original languageEnglish
    JournalAmerican Journal of Veterinary Research
    Volume73
    Issue number11
    Pages (from-to)1787-1793
    Number of pages7
    ISSN0002-9645
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Animal diseases
    • Viral diseases
    • Bovine herpesvirus 1
    • Rhinotracheitis
    • Cattle
    • Herds
    • Mass campaigns
    • Vaccination
    • Long term
    • Impact
    • Transmission reduction
    • Hyperimmunization
    • Glycoproteins
    • Seroconversion
    • Seasonality
    • Risk factors

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