Association between herpes simplex virus type 2 and HIV-1 in a population of married couples from Dakar, Senegal

M. Camara, M. Seydi, T.N. Dieye, P.S. Sow, S. Mboup, L. Kestens, W. Jennes

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Numerous studies suggest that herpes simplex virus type 2 (HSV-2) increases the risk of HIV-1 infection but recent clinical trials of HSV-2 suppressive therapy failed to show an effect. We assessed the putative association between HSV-2 and HIV-1 in a population of HIV-concordant-negative, HIV-1-discordant and HIV-1-concordant-positive married couples from Dakar, Senegal. In agreement with previous studies, we observed a strong overall association between HSV-2 and HIV-1 (odds ratio 4.61; P <0.001). However, this association was mainly determined by a low HSV-2 prevalence in HIV-concordant-negative couples compared with HIV-1-discordant and HIV-1-concordant-positive couples (23% versus 59% and 66%, respectively; P <0.001). We observed no further differences in HSV-2 prevalence between HIV-1-discordant and HIV-1-concordant-positive couples (59% and 66%, respectively; P = 0.483). Neither the index (59% versus 62%, P = 1.000) nor recipient partners (41% versus 63%, P = 0.131) in HIV-1-discordant and HIV-1-concordant-positive couples showed significant differences in HSV-2 prevalence. HSV-2 does not constitute a clear risk factor for HIV-1 infection in this population.
    Original languageEnglish
    JournalInternational Journal of STD & AIDS
    Volume23
    Issue number11
    Pages (from-to)810-814
    Number of pages5
    ISSN0956-4624
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Viral diseases
    • HIV
    • AIDS
    • Co-infections
    • Sexually transmitted diseases
    • STD
    • Herpes simplex virus type 2
    • HSV-2
    • Prevalence
    • Discordance
    • Couples
    • Associations
    • Risk
    • Senegal
    • Africa-West

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