Association between herpes simplex virus type 2 and HIV-1 in a population of married couples from Dakar, Senegal

M. Camara, M. Seydi, T.N. Dieye, P.S. Sow, S. Mboup, L. Kestens, W. Jennes

Research output: Contribution to journalA1: Web of Science-article

Abstract

Numerous studies suggest that herpes simplex virus type 2 (HSV-2) increases the risk of HIV-1 infection but recent clinical trials of HSV-2 suppressive therapy failed to show an effect. We assessed the putative association between HSV-2 and HIV-1 in a population of HIV-concordant-negative, HIV-1-discordant and HIV-1-concordant-positive married couples from Dakar, Senegal. In agreement with previous studies, we observed a strong overall association between HSV-2 and HIV-1 (odds ratio 4.61; P <0.001). However, this association was mainly determined by a low HSV-2 prevalence in HIV-concordant-negative couples compared with HIV-1-discordant and HIV-1-concordant-positive couples (23% versus 59% and 66%, respectively; P <0.001). We observed no further differences in HSV-2 prevalence between HIV-1-discordant and HIV-1-concordant-positive couples (59% and 66%, respectively; P = 0.483). Neither the index (59% versus 62%, P = 1.000) nor recipient partners (41% versus 63%, P = 0.131) in HIV-1-discordant and HIV-1-concordant-positive couples showed significant differences in HSV-2 prevalence. HSV-2 does not constitute a clear risk factor for HIV-1 infection in this population.
Original languageEnglish
JournalInternational Journal of STD & AIDS
Volume23
Issue number11
Pages (from-to)810-814
Number of pages5
ISSN0956-4624
DOIs
Publication statusPublished - 2012

Keywords

  • Viral diseases
  • HIV
  • AIDS
  • Co-infections
  • Sexually transmitted diseases
  • STD
  • Herpes simplex virus type 2
  • HSV-2
  • Prevalence
  • Discordance
  • Couples
  • Associations
  • Risk
  • Senegal
  • Africa-West

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