Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients

R Speeckaert, R Colebunders, JR Boelaert, L Brochez, J Van Acker, F Van Wanzeele, R Hemmer, MM Speeckaert, C Verhofstede, M De Buyzere, V Arendt, J Plum, JR Delanghe

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by a genetic polymorphism leading to three major phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p < 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p < 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp phenotypes in the pathogenesis of KS, which may be due to a difference in skin immunosurveillance between the Hp phenotypes.
    Original languageEnglish
    JournalArchives of Dermatological Research
    Volume303
    Issue number10
    Pages (from-to)763-769
    Number of pages7
    ISSN0340-3696
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • HIV
    • AIDS
    • Kaposi sarcoma
    • Herpes virus type 8
    • Disease progression
    • Immunosuppression
    • Risk factors
    • Associations
    • Haptoglobin
    • Plasma proteins
    • Polymorphism
    • Phenotyping
    • Belgium
    • Luxembourg
    • Europe-West

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