Association of HIV infection with anal and penile low-risk human papillomavirus infections among men who have sex with men in Amsterdam: the HIV & HPV in MSM study

Camiel A H Welling, Sofie H Mooij, Marianne van der Sande, Martijn S van Rooijen, Wilma F Vermeulen-Oost, Audrey J King, Arne van Eeden, Daniëlle A M Heideman, Ineke G Stolte, Maarten F Schim van der Loeff

Research output: Contribution to journalA1: Web of Science-articlepeer-review


BACKGROUND: This study among men who have sex with men (MSM) aimed to (1) assess prevalence of anogenital low-risk human papillomavirus (lrHPV) infections, (2) evaluate associations with HIV infection, and (3) investigate lrHPV concordance.

METHODS: In 2010 to 2011, MSM 18 years or older were recruited in Amsterdam, the Netherlands, and provided anal and penile self-swabs (HIV & HPV in MSM study). Using the HPV SPF10-PCR/DEIA/LiPA25 system, the presence of lrHPV types 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 68/73, 70, and 74 could be detected. Logistic regression with generalized estimating equations was used to assess the independent effect of HIV on lrHPV infections. The model was repeated for lrHPV subcategories (nononcogenic and weakly oncogenic infections separately). Concordance was defined as detection of the same lrHPV type in both self-swabs of one individual.

RESULTS: A total of 778 MSM were included, of whom 317 (41%) were HIV positive (median CD4 count at enrollment, 530 cells/mm). Prevalence of anal lrHPV was 45% (95% confidence interval [CI], 41%-50%) in HIV-negative MSM and 69% (95% CI, 64%-74%) in HIV-positive MSM. Prevalence of penile lrHPV was 20% (95% CI, 16%-24%) and 37% (95% CI, 31%-42%), respectively. In multivariable analysis, HIV infection was independently associated with anal (adjusted odds ratio [aOR], 1.9; 95% CI, 1.5-2.3) and penile lrHPV (aOR, 2.0; 95% CI, 1.4-2.7). Nononcogenic and weakly oncogenic lrHPV subcategories showed a similar pattern of association. Anal lrHPV infections were strongly associated with the presence of a type-concordant penile infection (aOR, 5.8; 95% CI, 4.4-7.5) and vice versa (aOR, 5.7; 95% CI, 4.4-7.5).

CONCLUSIONS: Anal and penile infections with lrHPV are common in MSM. HIV infection was an independent determinant for lrHPV infections.

Original languageEnglish
JournalSexually Transmitted Diseases
Issue number6
Pages (from-to)297-304
Number of pages8
Publication statusPublished - 2015


  • Adult
  • Anal Canal/virology
  • Anus Diseases/epidemiology
  • HIV Infections/epidemiology
  • Homosexuality, Male
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Netherlands/epidemiology
  • Odds Ratio
  • Papillomavirus Infections/epidemiology
  • Penile Diseases/epidemiology
  • Penis/virology
  • Prevalence
  • Prospective Studies
  • Risk Factors


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