TY - JOUR
T1 - Association of HIV infection with anal and penile low-risk human papillomavirus infections among men who have sex with men in Amsterdam: the HIV & HPV in MSM study
AU - Welling, Camiel A H
AU - Mooij, Sofie H
AU - van der Sande, Marianne
AU - van Rooijen, Martijn S
AU - Vermeulen-Oost, Wilma F
AU - King, Audrey J
AU - van Eeden, Arne
AU - Heideman, Daniëlle A M
AU - Stolte, Ineke G
AU - Schim van der Loeff, Maarten F
N1 - NPP
PY - 2015
Y1 - 2015
N2 - BACKGROUND: This study among men who have sex with men (MSM) aimed to (1) assess prevalence of anogenital low-risk human papillomavirus (lrHPV) infections, (2) evaluate associations with HIV infection, and (3) investigate lrHPV concordance.METHODS: In 2010 to 2011, MSM 18 years or older were recruited in Amsterdam, the Netherlands, and provided anal and penile self-swabs (HIV & HPV in MSM study). Using the HPV SPF10-PCR/DEIA/LiPA25 system, the presence of lrHPV types 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 68/73, 70, and 74 could be detected. Logistic regression with generalized estimating equations was used to assess the independent effect of HIV on lrHPV infections. The model was repeated for lrHPV subcategories (nononcogenic and weakly oncogenic infections separately). Concordance was defined as detection of the same lrHPV type in both self-swabs of one individual.RESULTS: A total of 778 MSM were included, of whom 317 (41%) were HIV positive (median CD4 count at enrollment, 530 cells/mm). Prevalence of anal lrHPV was 45% (95% confidence interval [CI], 41%-50%) in HIV-negative MSM and 69% (95% CI, 64%-74%) in HIV-positive MSM. Prevalence of penile lrHPV was 20% (95% CI, 16%-24%) and 37% (95% CI, 31%-42%), respectively. In multivariable analysis, HIV infection was independently associated with anal (adjusted odds ratio [aOR], 1.9; 95% CI, 1.5-2.3) and penile lrHPV (aOR, 2.0; 95% CI, 1.4-2.7). Nononcogenic and weakly oncogenic lrHPV subcategories showed a similar pattern of association. Anal lrHPV infections were strongly associated with the presence of a type-concordant penile infection (aOR, 5.8; 95% CI, 4.4-7.5) and vice versa (aOR, 5.7; 95% CI, 4.4-7.5).CONCLUSIONS: Anal and penile infections with lrHPV are common in MSM. HIV infection was an independent determinant for lrHPV infections.
AB - BACKGROUND: This study among men who have sex with men (MSM) aimed to (1) assess prevalence of anogenital low-risk human papillomavirus (lrHPV) infections, (2) evaluate associations with HIV infection, and (3) investigate lrHPV concordance.METHODS: In 2010 to 2011, MSM 18 years or older were recruited in Amsterdam, the Netherlands, and provided anal and penile self-swabs (HIV & HPV in MSM study). Using the HPV SPF10-PCR/DEIA/LiPA25 system, the presence of lrHPV types 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 68/73, 70, and 74 could be detected. Logistic regression with generalized estimating equations was used to assess the independent effect of HIV on lrHPV infections. The model was repeated for lrHPV subcategories (nononcogenic and weakly oncogenic infections separately). Concordance was defined as detection of the same lrHPV type in both self-swabs of one individual.RESULTS: A total of 778 MSM were included, of whom 317 (41%) were HIV positive (median CD4 count at enrollment, 530 cells/mm). Prevalence of anal lrHPV was 45% (95% confidence interval [CI], 41%-50%) in HIV-negative MSM and 69% (95% CI, 64%-74%) in HIV-positive MSM. Prevalence of penile lrHPV was 20% (95% CI, 16%-24%) and 37% (95% CI, 31%-42%), respectively. In multivariable analysis, HIV infection was independently associated with anal (adjusted odds ratio [aOR], 1.9; 95% CI, 1.5-2.3) and penile lrHPV (aOR, 2.0; 95% CI, 1.4-2.7). Nononcogenic and weakly oncogenic lrHPV subcategories showed a similar pattern of association. Anal lrHPV infections were strongly associated with the presence of a type-concordant penile infection (aOR, 5.8; 95% CI, 4.4-7.5) and vice versa (aOR, 5.7; 95% CI, 4.4-7.5).CONCLUSIONS: Anal and penile infections with lrHPV are common in MSM. HIV infection was an independent determinant for lrHPV infections.
KW - Adult
KW - Anal Canal/virology
KW - Anus Diseases/epidemiology
KW - HIV Infections/epidemiology
KW - Homosexuality, Male
KW - Humans
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Netherlands/epidemiology
KW - Odds Ratio
KW - Papillomavirus Infections/epidemiology
KW - Penile Diseases/epidemiology
KW - Penis/virology
KW - Prevalence
KW - Prospective Studies
KW - Risk Factors
U2 - 10.1097/OLQ.0000000000000278
DO - 10.1097/OLQ.0000000000000278
M3 - A1: Web of Science-article
C2 - 25970305
VL - 42
SP - 297
EP - 304
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
SN - 0148-5717
IS - 6
ER -