Asymptomatic Leishmania infection: a new challenge for Leishmania control

Om Prakash Singh, Epco Hasker, David Sacks, Marleen Boelaert, Shyam Sundar

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Visceral leishmaniasis (VL) is a serious parasitic disease, causing high morbidity and mortality in the developing world. The pathogenesis of VL is complex, and the clinical presentation ranges from asymptomatic infection to severe and fatal disease. Despite a wealth of research on the full-blown "clinical VL" syndrome, asymptomatic leishmania infections remain poorly understood. Asymptomatic infection could present a major challenge for control programs if its infectiousness is confirmed. In this viewpoint, we highlight the crucial knowledge gaps as well as the obstacles in research on asymptomatic leishmanial infection. Research in this area is essential for the development of more-effective VL control strategies.

    Original languageEnglish
    JournalClinical Infectious Diseases
    Volume58
    Issue number10
    Pages (from-to)1424-1429
    ISSN1058-4838
    DOIs
    Publication statusPublished - 2014

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