Bloodstream infections among HIV-infected outpatients, Southeast Asia

JK Varma; KD McCarthy; T Tasaneeyapan; P Monkongdee; ME Kimerling; E Buntheoun; D Sculier; C Keo; P Phanuphak; N Teeratakulpisarn; N Udomsantisuk; NH Dung; NT Lan; NT Yen; KP Cain

doi:10.3201/eid1610.091686

Bloodstream infections among HIV-infected outpatients, Southeast Asia

JK Varma, KD McCarthy, T Tasaneeyapan, P Monkongdee, ME Kimerling, E Buntheoun, D Sculier, C Keo, P Phanuphak, N Teeratakulpisarn, N Udomsantisuk, NH Dung, NT Lan, NT Yen, KP Cain

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Bloodstream infections (BSIs) are a major cause of illness in HIV-infected persons. To evaluate prevalence of and risk factors for BSIs in 2,009 HIV-infected outpatients in Cambodia, Thailand, and Vietnam, we performed a single Myco/F Lytic blood culture. Fifty-eight (2.9%) had a clinically significant BSI (i.e., a blood culture positive for an organism known to be a pathogen). Mycobacterium tuberculosis accounted for 31 (54%) of all BSIs, followed by fungi (13 [22%]) and bacteria (9 [16%]). Of patients for whom data were recorded about antiretroviral therapy, 0 of 119 who had received antiretroviral therapy for >/=14 days had a BSI, compared with 3% of 1,801 patients who had not. In multivariate analysis, factors consistently associated with BSI were fever, low CD4+ T-lymphocyte count, abnormalities on chest radiograph, and signs or symptoms of abdominal illness. For HIV-infected outpatients with these risk factors, clinicians should place their highest priority on diagnosing tuberculosis

Original language	English
Journal	Emerging Infectious Diseases
Volume	16
Issue number	10
Pages (from-to)	1569-1575
Number of pages	7
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid1610.091686
Publication status	Published - 2010

Keywords

B780-tropical-medicine
Viral diseases
HIV
AIDS
Outpatients
Blood-borne diseases
Co-infections
Bacterial diseases
Tuberculosis
Mycobacterium tuberculosis
Fungi
Risk factors
Fever
CD4 lymphocyte count
Radiography
Abdominal
Diagnosis
Asia-Southeast

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10.3201/eid1610.091686

http://lib.itg.be/pdf/itg/2010/2010eidi1569.pdf

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Varma, JK., McCarthy, KD., Tasaneeyapan, T., Monkongdee, P., Kimerling, ME., Buntheoun, E., Sculier, D., Keo, C., Phanuphak, P., Teeratakulpisarn, N., Udomsantisuk, N., Dung, NH., Lan, NT., Yen, NT., & Cain, KP. (2010). Bloodstream infections among HIV-infected outpatients, Southeast Asia. Emerging Infectious Diseases, 16(10), 1569-1575. https://doi.org/10.3201/eid1610.091686

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title = "Bloodstream infections among HIV-infected outpatients, Southeast Asia",

abstract = "Bloodstream infections (BSIs) are a major cause of illness in HIV-infected persons. To evaluate prevalence of and risk factors for BSIs in 2,009 HIV-infected outpatients in Cambodia, Thailand, and Vietnam, we performed a single Myco/F Lytic blood culture. Fifty-eight (2.9%) had a clinically significant BSI (i.e., a blood culture positive for an organism known to be a pathogen). Mycobacterium tuberculosis accounted for 31 (54%) of all BSIs, followed by fungi (13 [22%]) and bacteria (9 [16%]). Of patients for whom data were recorded about antiretroviral therapy, 0 of 119 who had received antiretroviral therapy for >/=14 days had a BSI, compared with 3% of 1,801 patients who had not. In multivariate analysis, factors consistently associated with BSI were fever, low CD4+ T-lymphocyte count, abnormalities on chest radiograph, and signs or symptoms of abdominal illness. For HIV-infected outpatients with these risk factors, clinicians should place their highest priority on diagnosing tuberculosis",

keywords = "B780-tropical-medicine, Viral diseases, HIV, AIDS, Outpatients, Blood-borne diseases, Co-infections, Bacterial diseases, Tuberculosis, Mycobacterium tuberculosis, Fungi, Risk factors, Fever, CD4 lymphocyte count, Radiography, Abdominal, Diagnosis, Asia-Southeast",

author = "JK Varma and KD McCarthy and T Tasaneeyapan and P Monkongdee and ME Kimerling and E Buntheoun and D Sculier and C Keo and P Phanuphak and N Teeratakulpisarn and N Udomsantisuk and NH Dung and NT Lan and NT Yen and KP Cain",

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Varma, JK, McCarthy, KD, Tasaneeyapan, T, Monkongdee, P, Kimerling, ME, Buntheoun, E, Sculier, D, Keo, C, Phanuphak, P, Teeratakulpisarn, N, Udomsantisuk, N, Dung, NH, Lan, NT, Yen, NT & Cain, KP 2010, 'Bloodstream infections among HIV-infected outpatients, Southeast Asia', Emerging Infectious Diseases, vol. 16, no. 10, pp. 1569-1575. https://doi.org/10.3201/eid1610.091686

TY - JOUR

T1 - Bloodstream infections among HIV-infected outpatients, Southeast Asia

AU - Varma, JK

AU - McCarthy, KD

AU - Tasaneeyapan, T

AU - Monkongdee, P

AU - Kimerling, ME

AU - Buntheoun, E

AU - Sculier, D

AU - Keo, C

AU - Phanuphak, P

AU - Teeratakulpisarn, N

AU - Udomsantisuk, N

AU - Dung, NH

AU - Lan, NT

AU - Yen, NT

AU - Cain, KP

N1 - ITG-C7B; CLINIC; U-HIVCLI; JIF; DOI; PDF; Abstract; DSPACE

PY - 2010

Y1 - 2010

N2 - Bloodstream infections (BSIs) are a major cause of illness in HIV-infected persons. To evaluate prevalence of and risk factors for BSIs in 2,009 HIV-infected outpatients in Cambodia, Thailand, and Vietnam, we performed a single Myco/F Lytic blood culture. Fifty-eight (2.9%) had a clinically significant BSI (i.e., a blood culture positive for an organism known to be a pathogen). Mycobacterium tuberculosis accounted for 31 (54%) of all BSIs, followed by fungi (13 [22%]) and bacteria (9 [16%]). Of patients for whom data were recorded about antiretroviral therapy, 0 of 119 who had received antiretroviral therapy for >/=14 days had a BSI, compared with 3% of 1,801 patients who had not. In multivariate analysis, factors consistently associated with BSI were fever, low CD4+ T-lymphocyte count, abnormalities on chest radiograph, and signs or symptoms of abdominal illness. For HIV-infected outpatients with these risk factors, clinicians should place their highest priority on diagnosing tuberculosis

AB - Bloodstream infections (BSIs) are a major cause of illness in HIV-infected persons. To evaluate prevalence of and risk factors for BSIs in 2,009 HIV-infected outpatients in Cambodia, Thailand, and Vietnam, we performed a single Myco/F Lytic blood culture. Fifty-eight (2.9%) had a clinically significant BSI (i.e., a blood culture positive for an organism known to be a pathogen). Mycobacterium tuberculosis accounted for 31 (54%) of all BSIs, followed by fungi (13 [22%]) and bacteria (9 [16%]). Of patients for whom data were recorded about antiretroviral therapy, 0 of 119 who had received antiretroviral therapy for >/=14 days had a BSI, compared with 3% of 1,801 patients who had not. In multivariate analysis, factors consistently associated with BSI were fever, low CD4+ T-lymphocyte count, abnormalities on chest radiograph, and signs or symptoms of abdominal illness. For HIV-infected outpatients with these risk factors, clinicians should place their highest priority on diagnosing tuberculosis

KW - B780-tropical-medicine

KW - Viral diseases

KW - HIV

KW - AIDS

KW - Outpatients

KW - Blood-borne diseases

KW - Co-infections

KW - Bacterial diseases

KW - Tuberculosis

KW - Mycobacterium tuberculosis

KW - Fungi

KW - Risk factors

KW - Fever

KW - CD4 lymphocyte count

KW - Radiography

KW - Abdominal

KW - Diagnosis

KW - Asia-Southeast

U2 - 10.3201/eid1610.091686

DO - 10.3201/eid1610.091686

M3 - A1: Web of Science-article

C2 - 20875282

SN - 1080-6040

VL - 16

SP - 1569

EP - 1575

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 10

ER -

Bloodstream infections among HIV-infected outpatients, Southeast Asia

Abstract

Keywords

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