Bloodstream infections among HIV-infected outpatients, Southeast Asia

JK Varma, KD McCarthy, T Tasaneeyapan, P Monkongdee, ME Kimerling, E Buntheoun, D Sculier, C Keo, P Phanuphak, N Teeratakulpisarn, N Udomsantisuk, NH Dung, NT Lan, NT Yen, KP Cain

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Bloodstream infections (BSIs) are a major cause of illness in HIV-infected persons. To evaluate prevalence of and risk factors for BSIs in 2,009 HIV-infected outpatients in Cambodia, Thailand, and Vietnam, we performed a single Myco/F Lytic blood culture. Fifty-eight (2.9%) had a clinically significant BSI (i.e., a blood culture positive for an organism known to be a pathogen). Mycobacterium tuberculosis accounted for 31 (54%) of all BSIs, followed by fungi (13 [22%]) and bacteria (9 [16%]). Of patients for whom data were recorded about antiretroviral therapy, 0 of 119 who had received antiretroviral therapy for >/=14 days had a BSI, compared with 3% of 1,801 patients who had not. In multivariate analysis, factors consistently associated with BSI were fever, low CD4+ T-lymphocyte count, abnormalities on chest radiograph, and signs or symptoms of abdominal illness. For HIV-infected outpatients with these risk factors, clinicians should place their highest priority on diagnosing tuberculosis
    Original languageEnglish
    JournalEmerging Infectious Diseases
    Volume16
    Issue number10
    Pages (from-to)1569-1575
    Number of pages7
    ISSN1080-6040
    DOIs
    Publication statusPublished - 2010

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • HIV
    • AIDS
    • Outpatients
    • Blood-borne diseases
    • Co-infections
    • Bacterial diseases
    • Tuberculosis
    • Mycobacterium tuberculosis
    • Fungi
    • Risk factors
    • Fever
    • CD4 lymphocyte count
    • Radiography
    • Abdominal
    • Diagnosis
    • Asia-Southeast

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