Buruli ulcer: a review of in vitro tests to screen natural products for activity against Mycobacterium ulcerans

A Yemoa, J Gbenou, D Affolabi, M Moudachirou, A Bigot, S Anagonou, F Portaels, J Quetin-Leclercq, A Martin

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Buruli ulcer (BU), caused by MYCOBACTERIUM ULCERANS, has recently been recognized by the World Health Organization (WHO) as an important emerging disease. It is largely a problem of the poor in remote rural areas and has emerged as an important cause of human suffering. While antimycobacterial therapy is often effective for the earliest nodular or ulcerative lesions, for advanced ulcerated lesions, surgery is sometimes necessary. Antimycobacterial drugs may also prevent relapses or disseminated infections. Efficient alternatives different from surgery are presently explored because this treatment deals with huge restrictive factors such as the necessity of prolonged hospitalization, its high cost, and the scars after surgery. Traditional treatment remains the first option for poor populations of remote areas who may have problems of accessibility to synthetic products because of their high cost. The search for efficient natural products active on M. ULCERANS should then be encouraged because they are part of the natural heritage of these populations; they are affordable financially and can be used at the earliest stage. This review provides a number of tests that will help to evaluate the antimycobacterial activity of natural products against M. ULCERANS, which are adapted to its slow growing rate, and lists active extracts published up to now in Medline.
    Original languageEnglish
    JournalPlanta Medica
    Volume77
    Issue number6
    Pages (from-to)641-646
    ISSN0032-0943
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Bacterial diseases
    • Buruli ulcer
    • Mycobacterium ulcerans
    • Treatment
    • Antimicrobial activity
    • Natural products
    • Evaluation
    • Effectiveness
    • In vitro
    • Screening
    • Review of the literature

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