Can biomarkers of oxidative stress in serum predict disease severity in West Nile virus infection? A pilot study

Maxim Van Herreweghe, Annelies Breynaert, Tess De Bruyne, Corneliu Petru Popescu, Simin-Aysel Florescu, Yaniv Lustig, Eli Schwartz, Federico Giovanni Gobbi, Nina Hermans, Ralph Huits

    Research output: Contribution to journalA1: Web of Science-articlepeer-review


    West Nile virus (WNV) can cause asymptomatic infection in humans, result in self-limiting febrile illness, or lead to severe West Nile Neuroinvasive disease (WNND). We conducted a pilot study to compare selected biomarkers of oxidative stress in sera of viremic West Nile virus patients and asymptomatic infected blood donors to investigate their potential as predictors of disease severity. We found that total oxidant status was elevated in WNND and in uncomplicated WNV infections (median 9.05 (IQR 8.37 to 9.74) and 7.14 (7.03 to 7.25) µmol H 2O 2 equiv./L, respectively) compared to asymptomatic infections (0.11 (0.07 to 0.19) µmol H 2O 2 equiv./L) ( p = 0.048). MDA levels showed a similar trend to TOS, but differences were not significant at α = 0.05. Total antioxidant status did not differ significantly between different disease severity groups. Oxidative stress appears to be associated with more severe disease in WNV-infected patients. Our preliminary findings warrant prospective studies to investigate the correlation of oxidative stress with clinical outcomes and severity of WNV infection.

    Original languageEnglish
    Article number207
    JournalTropical Medicine and Infectious Disease
    Issue number9
    Number of pages6
    Publication statusPublished - 2022


    • oxidative stress
    • West Nile virus
    • West Nile Fever
    • West Nile Neuroinvasive disease
    • Flaviviridae
    • biomarkers

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