Can biomarkers of oxidative stress in serum predict disease severity in West Nile virus infection? A pilot study

Maxim Van Herreweghe; Annelies Breynaert; Tess De Bruyne; Corneliu Petru Popescu; Simin-Aysel Florescu; Yaniv Lustig; Eli Schwartz; Federico Giovanni Gobbi; Nina Hermans; Ralph Huits

doi:10.3390/tropicalmed7090207

Can biomarkers of oxidative stress in serum predict disease severity in West Nile virus infection? A pilot study

Maxim Van Herreweghe, Annelies Breynaert, Tess De Bruyne, Corneliu Petru Popescu, Simin-Aysel Florescu, Yaniv Lustig, Eli Schwartz, Federico Giovanni Gobbi, Nina Hermans, Ralph Huits

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Abstract

West Nile virus (WNV) can cause asymptomatic infection in humans, result in self-limiting febrile illness, or lead to severe West Nile Neuroinvasive disease (WNND). We conducted a pilot study to compare selected biomarkers of oxidative stress in sera of viremic West Nile virus patients and asymptomatic infected blood donors to investigate their potential as predictors of disease severity. We found that total oxidant status was elevated in WNND and in uncomplicated WNV infections (median 9.05 (IQR 8.37 to 9.74) and 7.14 (7.03 to 7.25) µmol H 2O 2 equiv./L, respectively) compared to asymptomatic infections (0.11 (0.07 to 0.19) µmol H 2O 2 equiv./L) ( p = 0.048). MDA levels showed a similar trend to TOS, but differences were not significant at α = 0.05. Total antioxidant status did not differ significantly between different disease severity groups. Oxidative stress appears to be associated with more severe disease in WNV-infected patients. Our preliminary findings warrant prospective studies to investigate the correlation of oxidative stress with clinical outcomes and severity of WNV infection.

Original language	English
Article number	207
Journal	Tropical Medicine and Infectious Disease
Volume	7
Issue number	9
Number of pages	6
ISSN	2414-6366
DOIs	https://doi.org/10.3390/tropicalmed7090207
Publication status	Published - 2022

Keywords

oxidative stress
West Nile virus
West Nile Fever
West Nile Neuroinvasive disease
Flaviviridae
biomarkers
ASSOCIATION

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10.3390/tropicalmed7090207Licence: CC BY

2022tmid0207Final published version, 511 KBLicence: CC BY

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Van Herreweghe, M., Breynaert, A., De Bruyne, T., Popescu, C. P., Florescu, S.-A., Lustig, Y., Schwartz, E., Gobbi, F. G., Hermans, N., & Huits, R. (2022). Can biomarkers of oxidative stress in serum predict disease severity in West Nile virus infection? A pilot study. Tropical Medicine and Infectious Disease, 7(9), Article 207. https://doi.org/10.3390/tropicalmed7090207

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title = "Can biomarkers of oxidative stress in serum predict disease severity in West Nile virus infection? A pilot study",

abstract = "West Nile virus (WNV) can cause asymptomatic infection in humans, result in self-limiting febrile illness, or lead to severe West Nile Neuroinvasive disease (WNND). We conducted a pilot study to compare selected biomarkers of oxidative stress in sera of viremic West Nile virus patients and asymptomatic infected blood donors to investigate their potential as predictors of disease severity. We found that total oxidant status was elevated in WNND and in uncomplicated WNV infections (median 9.05 (IQR 8.37 to 9.74) and 7.14 (7.03 to 7.25) µmol H 2O 2 equiv./L, respectively) compared to asymptomatic infections (0.11 (0.07 to 0.19) µmol H 2O 2 equiv./L) ( p = 0.048). MDA levels showed a similar trend to TOS, but differences were not significant at α = 0.05. Total antioxidant status did not differ significantly between different disease severity groups. Oxidative stress appears to be associated with more severe disease in WNV-infected patients. Our preliminary findings warrant prospective studies to investigate the correlation of oxidative stress with clinical outcomes and severity of WNV infection. ",

keywords = "oxidative stress, West Nile virus, West Nile Fever, West Nile Neuroinvasive disease, Flaviviridae, biomarkers, ASSOCIATION",

author = "{Van Herreweghe}, Maxim and Annelies Breynaert and {De Bruyne}, Tess and Popescu, {Corneliu Petru} and Simin-Aysel Florescu and Yaniv Lustig and Eli Schwartz and Gobbi, {Federico Giovanni} and Nina Hermans and Ralph Huits",

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T1 - Can biomarkers of oxidative stress in serum predict disease severity in West Nile virus infection? A pilot study

AU - Van Herreweghe, Maxim

AU - Breynaert, Annelies

AU - De Bruyne, Tess

AU - Popescu, Corneliu Petru

AU - Florescu, Simin-Aysel

AU - Lustig, Yaniv

AU - Schwartz, Eli

AU - Gobbi, Federico Giovanni

AU - Hermans, Nina

AU - Huits, Ralph

N1 - FTX; DOAJ; (CC BY 4.0)

PY - 2022

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N2 - West Nile virus (WNV) can cause asymptomatic infection in humans, result in self-limiting febrile illness, or lead to severe West Nile Neuroinvasive disease (WNND). We conducted a pilot study to compare selected biomarkers of oxidative stress in sera of viremic West Nile virus patients and asymptomatic infected blood donors to investigate their potential as predictors of disease severity. We found that total oxidant status was elevated in WNND and in uncomplicated WNV infections (median 9.05 (IQR 8.37 to 9.74) and 7.14 (7.03 to 7.25) µmol H 2O 2 equiv./L, respectively) compared to asymptomatic infections (0.11 (0.07 to 0.19) µmol H 2O 2 equiv./L) ( p = 0.048). MDA levels showed a similar trend to TOS, but differences were not significant at α = 0.05. Total antioxidant status did not differ significantly between different disease severity groups. Oxidative stress appears to be associated with more severe disease in WNV-infected patients. Our preliminary findings warrant prospective studies to investigate the correlation of oxidative stress with clinical outcomes and severity of WNV infection.

AB - West Nile virus (WNV) can cause asymptomatic infection in humans, result in self-limiting febrile illness, or lead to severe West Nile Neuroinvasive disease (WNND). We conducted a pilot study to compare selected biomarkers of oxidative stress in sera of viremic West Nile virus patients and asymptomatic infected blood donors to investigate their potential as predictors of disease severity. We found that total oxidant status was elevated in WNND and in uncomplicated WNV infections (median 9.05 (IQR 8.37 to 9.74) and 7.14 (7.03 to 7.25) µmol H 2O 2 equiv./L, respectively) compared to asymptomatic infections (0.11 (0.07 to 0.19) µmol H 2O 2 equiv./L) ( p = 0.048). MDA levels showed a similar trend to TOS, but differences were not significant at α = 0.05. Total antioxidant status did not differ significantly between different disease severity groups. Oxidative stress appears to be associated with more severe disease in WNV-infected patients. Our preliminary findings warrant prospective studies to investigate the correlation of oxidative stress with clinical outcomes and severity of WNV infection.

KW - oxidative stress

KW - West Nile virus

KW - West Nile Fever

KW - West Nile Neuroinvasive disease

KW - Flaviviridae

KW - biomarkers

KW - ASSOCIATION

U2 - 10.3390/tropicalmed7090207

DO - 10.3390/tropicalmed7090207

M3 - A1: Web of Science-article

C2 - 36136618

SN - 2414-6366

VL - 7

JO - Tropical Medicine and Infectious Disease

JF - Tropical Medicine and Infectious Disease

IS - 9

M1 - 207

ER -

Can biomarkers of oxidative stress in serum predict disease severity in West Nile virus infection? A pilot study

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