Can molecular methods detect 1% isoniazid resistance in Mycobacterium tuberculosis?

D.B. Folkvardsen, E. Svensson, V.O. Thomsen, E.M. Rasmussen, D. Bang, J. Werngren, S. Hoffner, D. Hillemann, L. Rigouts

Research output: Contribution to journalA1: Web of Science-article

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Abstract

Patients may harbour both drug susceptible and resistant bacteria, i.e. heteroresistance. We studied mixtures of isoniazid resistant and susceptible Mycobacterium tuberculosis strains. Conventional drug susceptibility testing was the most sensitive whereas the line probe assay and sequencing were not able to detect the clinically relevant 1% proportion of resistant bacteria.
Original languageEnglish
JournalJournal of Clinical Microbiology
Volume51
Issue number5
Pages (from-to)1596-1599
Number of pages4
ISSN0095-1137
DOIs
Publication statusPublished - 2013

Keywords

  • Bacterial diseases
  • Tuberculosis
  • Mycobacterium tuberculosis
  • Drug resistance
  • Drug susceptibility
  • Isoniazid
  • Detection
  • Molecular diagnostic techniques
  • Strains
  • Sensitivity
  • Line probe assay
  • Sequencing
  • Laboratory techniques and procedures

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