Can molecular methods detect 1% isoniazid resistance in Mycobacterium tuberculosis?

D.B. Folkvardsen, E. Svensson, V.O. Thomsen, E.M. Rasmussen, D. Bang, J. Werngren, S. Hoffner, D. Hillemann, L. Rigouts

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Patients may harbour both drug susceptible and resistant bacteria, i.e. heteroresistance. We studied mixtures of isoniazid resistant and susceptible Mycobacterium tuberculosis strains. Conventional drug susceptibility testing was the most sensitive whereas the line probe assay and sequencing were not able to detect the clinically relevant 1% proportion of resistant bacteria.
Original languageEnglish
JournalJournal of Clinical Microbiology
Issue number5
Pages (from-to)1596-1599
Number of pages4
Publication statusPublished - 2013


  • Bacterial diseases
  • Tuberculosis
  • Mycobacterium tuberculosis
  • Drug resistance
  • Drug susceptibility
  • Isoniazid
  • Detection
  • Molecular diagnostic techniques
  • Strains
  • Sensitivity
  • Line probe assay
  • Sequencing
  • Laboratory techniques and procedures


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