Can previous associations of single nucleotide polymorphisms in the TLR2, NOD1, CXCR5, and IL10 genes in the susceptibility to and severity of Chlamydia trachomatis infections be confirmed?

Jelmer B. Jukema; Bernice M. Hoenderboom; Birgit H. B. van Benthem; Marianne A. B. Van der Sande; Henry J. C. de Vries; Christian J. P. A. Hoebe; Nicole H. T. M. Dukers-Muijrers; Caroline J. Bax; Servaas A. Morre; Sander Ouburg

doi:10.3390/pathogens10010048

Can previous associations of single nucleotide polymorphisms in the TLR2, NOD1, CXCR5, and IL10 genes in the susceptibility to and severity of Chlamydia trachomatis infections be confirmed?

Jelmer B. Jukema, Bernice M. Hoenderboom, Birgit H. B. van Benthem, Marianne A. B. Van der Sande, Henry J. C. de Vries, Christian J. P. A. Hoebe, Nicole H. T. M. Dukers-Muijrers, Caroline J. Bax, Servaas A. Morre, Sander Ouburg

Department of Public Health

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for TLR2 + 2477 G > A, NOD1 + 32656 T -> GG, CXCR5 + 10950 T > C, and IL10 - 1082 A > G. Results confirmed that NOD1 + 32656 T ->GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1-3.4, p = 0.02), but we did not observe an association with late complications. IL10 - 1082 A > G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1-7.1, p = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs' role in the susceptibility and severity of a CT infection.

Original language	English
Article number	48
Journal	Pathogens
Volume	10
Issue number	1
Number of pages	16
ISSN	2076-0817
DOIs	https://doi.org/10.3390/pathogens10010048
Publication status	Published - 2021

Keywords

Chlamydia trachomatis
single nucleotide polymorphism
SNP
susceptibility
severity

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Jukema, J. B., Hoenderboom, B. M., van Benthem, B. H. B., Van der Sande, M. A. B., de Vries, H. J. C., Hoebe, C. J. P. A., Dukers-Muijrers, N. H. T. M., Bax, C. J., Morre, S. A., & Ouburg, S. (2021). Can previous associations of single nucleotide polymorphisms in the TLR2, NOD1, CXCR5, and IL10 genes in the susceptibility to and severity of Chlamydia trachomatis infections be confirmed? Pathogens, 10(1), Article 48. https://doi.org/10.3390/pathogens10010048

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title = "Can previous associations of single nucleotide polymorphisms in the TLR2, NOD1, CXCR5, and IL10 genes in the susceptibility to and severity of Chlamydia trachomatis infections be confirmed?",

abstract = "Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for TLR2 + 2477 G > A, NOD1 + 32656 T -> GG, CXCR5 + 10950 T > C, and IL10 - 1082 A > G. Results confirmed that NOD1 + 32656 T ->GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1-3.4, p = 0.02), but we did not observe an association with late complications. IL10 - 1082 A > G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1-7.1, p = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs' role in the susceptibility and severity of a CT infection.",

keywords = "Chlamydia trachomatis, single nucleotide polymorphism, SNP, susceptibility, severity",

author = "Jukema, {Jelmer B.} and Hoenderboom, {Bernice M.} and {van Benthem}, {Birgit H. B.} and {Van der Sande}, {Marianne A. B.} and {de Vries}, {Henry J. C.} and Hoebe, {Christian J. P. A.} and Dukers-Muijrers, {Nicole H. T. M.} and Bax, {Caroline J.} and Morre, {Servaas A.} and Sander Ouburg",

note = "FTX; DOAJ; (CC BY 4.0)",

year = "2021",

doi = "10.3390/pathogens10010048",

language = "English",

volume = "10",

journal = "Pathogens",

issn = "2076-0817",

publisher = "MDPI AG",

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Jukema, JB, Hoenderboom, BM, van Benthem, BHB, Van der Sande, MAB, de Vries, HJC, Hoebe, CJPA, Dukers-Muijrers, NHTM, Bax, CJ, Morre, SA & Ouburg, S 2021, 'Can previous associations of single nucleotide polymorphisms in the TLR2, NOD1, CXCR5, and IL10 genes in the susceptibility to and severity of Chlamydia trachomatis infections be confirmed?', Pathogens, vol. 10, no. 1, 48. https://doi.org/10.3390/pathogens10010048

Can previous associations of single nucleotide polymorphisms in the TLR2, NOD1, CXCR5, and IL10 genes in the susceptibility to and severity of Chlamydia trachomatis infections be confirmed? / Jukema, Jelmer B.; Hoenderboom, Bernice M.; van Benthem, Birgit H. B. et al.
In: Pathogens, Vol. 10, No. 1, 48, 2021.

Research output: Contribution to journal › A1: Web of Science-article › peer-review