Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy

Carl Boodman; Yashpal S Chhonker; Daryl J Murry; Allison Mah; Jennifer Grant; Theodore Steiner; Michael Libman; Cesilia Nishi; Marthe Charles

doi:10.4269/ajtmh.18-0487

Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy

Carl Boodman, Yashpal S Chhonker, Daryl J Murry, Allison Mah, Jennifer Grant, Theodore Steiner, Michael Libman, Cesilia Nishi, Marthe Charles

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Disseminated strongyloidiasis is often fatal, despite treatment with oral albendazole and parenteral ivermectin (IVM). Here, we report elevated plasma IVM and albendazole sulfoxide concentrations in the context of extracorporeal membrane oxygenation and continuous renal replacement therapy in a patient with disseminated strongyloidiasis treated with subcutaneous IVM and nasogastric albenzadole. Despite elevated drug plasma concentrations, live filariform larvae were detected in endotracheal aspirates after 2 weeks of treatment.

Original language	English
Journal	The American Journal of Tropical Medicine and Hygiene
Volume	99
Issue number	5
Pages (from-to)	1194-1197
Number of pages	4
ISSN	1476-1645
DOIs	https://doi.org/10.4269/ajtmh.18-0487
Publication status	Published - Nov-2018
Externally published	Yes

Keywords

Albendazole/blood
Animals
Anthelmintics/blood
Extracorporeal Membrane Oxygenation
Humans
Ivermectin/blood
Larva/drug effects
Male
Middle Aged
Renal Dialysis
Strongyloides stercoralis/drug effects
Strongyloidiasis/blood

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Boodman, C., Chhonker, Y. S., Murry, D. J., Mah, A., Grant, J., Steiner, T., Libman, M., Nishi, C., & Charles, M. (2018). Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy . The American Journal of Tropical Medicine and Hygiene, 99(5), 1194-1197. https://doi.org/10.4269/ajtmh.18-0487

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title = "Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy ",

abstract = "Disseminated strongyloidiasis is often fatal, despite treatment with oral albendazole and parenteral ivermectin (IVM). Here, we report elevated plasma IVM and albendazole sulfoxide concentrations in the context of extracorporeal membrane oxygenation and continuous renal replacement therapy in a patient with disseminated strongyloidiasis treated with subcutaneous IVM and nasogastric albenzadole. Despite elevated drug plasma concentrations, live filariform larvae were detected in endotracheal aspirates after 2 weeks of treatment.",

keywords = "Albendazole/blood, Animals, Anthelmintics/blood, Extracorporeal Membrane Oxygenation, Humans, Ivermectin/blood, Larva/drug effects, Male, Middle Aged, Renal Dialysis, Strongyloides stercoralis/drug effects, Strongyloidiasis/blood",

author = "Carl Boodman and Chhonker, {Yashpal S} and Murry, {Daryl J} and Allison Mah and Jennifer Grant and Theodore Steiner and Michael Libman and Cesilia Nishi and Marthe Charles",

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Boodman, C, Chhonker, YS, Murry, DJ, Mah, A, Grant, J, Steiner, T, Libman, M, Nishi, C & Charles, M 2018, 'Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy ', The American Journal of Tropical Medicine and Hygiene, vol. 99, no. 5, pp. 1194-1197. https://doi.org/10.4269/ajtmh.18-0487

Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy . / Boodman, Carl; Chhonker, Yashpal S; Murry, Daryl J et al.
In: The American Journal of Tropical Medicine and Hygiene, Vol. 99, No. 5, 11.2018, p. 1194-1197.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Case Report

T2 - Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy

AU - Boodman, Carl

AU - Chhonker, Yashpal S

AU - Murry, Daryl J

AU - Mah, Allison

AU - Grant, Jennifer

AU - Steiner, Theodore

AU - Libman, Michael

AU - Nishi, Cesilia

AU - Charles, Marthe

N1 - FTX

PY - 2018/11

Y1 - 2018/11

N2 - Disseminated strongyloidiasis is often fatal, despite treatment with oral albendazole and parenteral ivermectin (IVM). Here, we report elevated plasma IVM and albendazole sulfoxide concentrations in the context of extracorporeal membrane oxygenation and continuous renal replacement therapy in a patient with disseminated strongyloidiasis treated with subcutaneous IVM and nasogastric albenzadole. Despite elevated drug plasma concentrations, live filariform larvae were detected in endotracheal aspirates after 2 weeks of treatment.

AB - Disseminated strongyloidiasis is often fatal, despite treatment with oral albendazole and parenteral ivermectin (IVM). Here, we report elevated plasma IVM and albendazole sulfoxide concentrations in the context of extracorporeal membrane oxygenation and continuous renal replacement therapy in a patient with disseminated strongyloidiasis treated with subcutaneous IVM and nasogastric albenzadole. Despite elevated drug plasma concentrations, live filariform larvae were detected in endotracheal aspirates after 2 weeks of treatment.

KW - Albendazole/blood

KW - Animals

KW - Anthelmintics/blood

KW - Extracorporeal Membrane Oxygenation

KW - Humans

KW - Ivermectin/blood

KW - Larva/drug effects

KW - Male

KW - Middle Aged

KW - Renal Dialysis

KW - Strongyloides stercoralis/drug effects

KW - Strongyloidiasis/blood

U2 - 10.4269/ajtmh.18-0487

DO - 10.4269/ajtmh.18-0487

M3 - A1: Web of Science-article

C2 - 30226142

SN - 1476-1645

VL - 99

SP - 1194

EP - 1197

JO - The American Journal of Tropical Medicine and Hygiene

JF - The American Journal of Tropical Medicine and Hygiene

IS - 5

ER -

Boodman C, Chhonker YS, Murry DJ, Mah A, Grant J, Steiner T et al. Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy . The American Journal of Tropical Medicine and Hygiene. 2018 Nov;99(5):1194-1197. doi: 10.4269/ajtmh.18-0487

Case Report: Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy

Abstract

Keywords

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