TY - JOUR
T1 - Case Report
T2 - Therapeutic threshold for rifampicin-resistant tuberculosis: a case report from Maputo, Mozambique
AU - Gonzaga, Lorena D M
AU - Gils, Tinne
AU - Decroo, Tom
AU - Jacobs, Bart K M
AU - Lynen, Lutgarde
N1 - CPDF
PY - 2021
Y1 - 2021
N2 - We present a case of a patient in Mozambique, who initiated treatment for rifampicin-resistant tuberculosis (RR-TB) without proof of resistance. For this patient, we estimated the probability of RR-TB using likelihood ratios of clinical arguments. The probability of RR-TB in Mozambique, positive HIV status, and treatment failure after a first treatment and after retreatment were included as confirming arguments, and a rapid molecular test showing rifampicin susceptibility as excluding argument. The therapeutic threshold to start treatment for RR-TB is unknown, but probably lower than 47% and should be calculated to guide clinical decisions.
AB - We present a case of a patient in Mozambique, who initiated treatment for rifampicin-resistant tuberculosis (RR-TB) without proof of resistance. For this patient, we estimated the probability of RR-TB using likelihood ratios of clinical arguments. The probability of RR-TB in Mozambique, positive HIV status, and treatment failure after a first treatment and after retreatment were included as confirming arguments, and a rapid molecular test showing rifampicin susceptibility as excluding argument. The therapeutic threshold to start treatment for RR-TB is unknown, but probably lower than 47% and should be calculated to guide clinical decisions.
U2 - 10.4269/ajtmh.20-0959
DO - 10.4269/ajtmh.20-0959
M3 - A1: Web of Science-article
C2 - 33556043
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
ER -