Case report: therapeutic threshold for rifampicin-resistant tuberculosis: a case report from Maputo, Mozambique

Lorena D M Gonzaga, Tinne Gils, Tom Decroo, Bart K M Jacobs, Lutgarde Lynen

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Abstract

We present a case of a patient in Mozambique, who initiated treatment for rifampicin-resistant tuberculosis (RR-TB) without proof of resistance. For this patient, we estimated the probability of RR-TB using likelihood ratios of clinical arguments. The probability of RR-TB in Mozambique, positive HIV status, and treatment failure after a first treatment and after retreatment were included as confirming arguments, and a rapid molecular test showing rifampicin susceptibility as excluding argument. The therapeutic threshold to start treatment for RR-TB is unknown, but probably lower than 47% and should be calculated to guide clinical decisions.

Original languageEnglish
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume104
Issue number4
Pages (from-to)1317-1320
Number of pages4
ISSN0002-9637
DOIs
Publication statusPublished - 2021

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