Case Report: Trypanosoma brucei Gambiense Human African Trypanosomiasis as the Cause of Fever in an Inpatient with Multiple Myeloma and HIV-1 Coinfection

Carl Boodman, Michael Libman, Momar Ndao, Cedric P Yansouni

Research output: Contribution to journalArticlepeer-review

Abstract

We report the case of a 64-year-old woman found to have urban-acquired Trypanosoma brucei (T.b.) gambiense human African trypanosomiasis (HAT) as the cause of sustained fever starting 9 months after returning to Canada from Democratic Republic of the Congo, in the context of concomitant multiple myeloma and HIV-1 coinfection. Approaches for the management of both clinical stages of T.b. gambiense HAT are well defined for endemic settings using current diagnostics and treatments. However, few data inform the diagnosis and management of patients with bone marrow suppression from active malignancy, recent anticancer therapy, or HIV coinfection. We discuss the implications of immunosuppression for diagnosis and management of T.b. gambiense HAT.

Original languageEnglish
JournalThe American Journal of Tropical Medicine and Hygiene
Volume101
Issue number1
Pages (from-to)123-125
Number of pages3
ISSN1476-1645
DOIs
Publication statusPublished - Jul-2019

Keywords

  • Coinfection
  • Congo/epidemiology
  • Female
  • Fever
  • HIV Infections/complications
  • HIV-1
  • Humans
  • Middle Aged
  • Multiple Myeloma/complications
  • Pentamidine/therapeutic use
  • Travel
  • Trypanocidal Agents/therapeutic use
  • Trypanosoma brucei gambiense
  • Trypanosomiasis, African/complications

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